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AB91008

Anti-HAP40 antibody

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(1 Publication)

Rabbit Polyclonal HAP40 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication.

View Alternative Names

F8a, Hap40, F8a1, 40-kDa huntingtin-associated protein, CpG island protein, Factor VIII intron 22 protein

1 Images
Western blot - Anti-HAP40 antibody (AB91008)
  • WB

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Western blot - Anti-HAP40 antibody (AB91008)

All lanes:

Western blot - Anti-HAP40 antibody (ab91008) at 1/500 dilution

All lanes:

Mouse brain lysate

Predicted band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

This antibody co-immunoprecipitates Hungtingtin protein (350 kDa)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: 5% Trehalose
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Huntingtin-associated protein 40 (HAP40) also known as F8A2 is a protein with a molecular weight of approximately 40 kDa. It expresses mainly in brain tissue with notable presence in neuronal cells. The protein localizes within the cytoplasm and associates with intracellular organelles. HAP40 contains domains that facilitate binding to other proteins playing a role in transport and cellular structural organization.
Biological function summary

HAP40 interacts with the huntingtin protein (HTT) forming a complex that influences cellular processes. The interaction with HTT suggests it helps modulate various cellular mechanisms such as vesicle trafficking cytoskeletal dynamics and regulation of endosome motility. These functions indicate that HAP40 acts as a co-factor in cellular transport systems particularly affecting neurons due to its high expression levels there.

Pathways

The association of HAP40 with HTT places it within significant neural pathways like vesicular transport and endocytic pathways. HAP40 affects processes related to the movement and positioning of vesicles inside cells. Its interaction with HTT links it to other proteins involved in these pathways such as the dynactin subunit p150Glued which facilitates vesicle transport along microtubules.

HAP40 has a strong connection to Huntington's disease a neurodegenerative disorder associated with mutant HTT. The abnormal interaction between the mutated HTT and HAP40 affects neuronal function and survival contributing to disease progression. Additionally studies implicate HAP40 in schizophrenia where its interaction with HTT might disrupt neural signaling and cognitive function. These associations make HAP40 a significant target for understanding and treating related neurological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity). The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed : 16476778).
See full target information F8a1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pediatrics 10:836591 PubMed35601428

2022

Distinct Epithelial Cell Profiles in Normal Versus Induced-Congenital Diaphragmatic Hernia Fetal Lungs.

Applications

Unspecified application

Species

Unspecified reactive species

Ana N Gonçalves,Jorge Correia-Pinto,Cristina Nogueira-Silva
View all publications
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