Anti-HAP40 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Huntingtin-associated protein 40 (HAP40) also known as F8A2 is a protein with a molecular weight of approximately 40 kDa. It expresses mainly in brain tissue with notable presence in neuronal cells. The protein localizes within the cytoplasm and associates with intracellular organelles. HAP40 contains domains that facilitate binding to other proteins playing a role in transport and cellular structural organization.

Biological function summary

HAP40 interacts with the huntingtin protein (HTT) forming a complex that influences cellular processes. The interaction with HTT suggests it helps modulate various cellular mechanisms such as vesicle trafficking cytoskeletal dynamics and regulation of endosome motility. These functions indicate that HAP40 acts as a co-factor in cellular transport systems particularly affecting neurons due to its high expression levels there.

Pathways

The association of HAP40 with HTT places it within significant neural pathways like vesicular transport and endocytic pathways. HAP40 affects processes related to the movement and positioning of vesicles inside cells. Its interaction with HTT links it to other proteins involved in these pathways such as the dynactin subunit p150Glued which facilitates vesicle transport along microtubules.

Associated diseases and disorders

HAP40 has a strong connection to Huntington's disease a neurodegenerative disorder associated with mutant HTT. The abnormal interaction between the mutated HTT and HAP40 affects neuronal function and survival contributing to disease progression. Additionally studies implicate HAP40 in schizophrenia where its interaction with HTT might disrupt neural signaling and cognitive function. These associations make HAP40 a significant target for understanding and treating related neurological conditions.