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AB78939

Anti-HAX1 antibody

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(3 Publications)

Rabbit Polyclonal HAX1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human HAX1.

View Alternative Names

HS1BP1, HAX1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1, HAX-1, HSP1BP-1

1 Images
Western blot - Anti-HAX1 antibody (AB78939)
  • WB

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Western blot - Anti-HAX1 antibody (AB78939)

Lane 1:

Western blot - Anti-HAX1 antibody (ab78939) at 1 µg/mL

Lane 2:

Western blot - Anti-HAX1 antibody (ab78939) at 2 µg/mL

All lanes:

Human brain tissue lysate at 15 µg

Predicted band size: 32 kDa

Observed band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human HAX1. The exact immunogen used to generate this antibody is proprietary information.

O00165

Specificity

At least four isoforms of HAX1 are known to exist. ab78939 is expected to recognize the longest isoform (HAX1a) as well as the shortest.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab78939 was purified by affinity chromatography via a peptide column
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HAX1 also known as HS-1 associated protein X-1 is a multifunctional protein with a mass of approximately 35 kDa. It plays a significant role in cellular activities by regulating various signaling pathways and maintaining cellular homeostasis. The expression of HAX1 is found in several tissues including the brain heart and skeletal muscle indicating its diverse functional importance across different cell types.
Biological function summary

HAX1 contributes to the stabilization of mitochondria by preventing apoptosis. It interacts with other proteins to form complexes that support cell survival. HAX1's involvement in mitochondrial functions highlights its role in regulating energy production and cellular stress responses. Its capacity to inhibit programmed cell death makes it essential for maintaining cell integrity under stress conditions.

Pathways

HAX1 is integral to the mitochondrial apoptosis pathway and also plays a part in the cytoskeletal signaling pathway. In the apoptosis pathway HAX1 interacts with proteins like BCL-2 to inhibit cell death ensuring cell survival. Additionally in the cytoskeletal signaling pathway HAX1 associates with cytoskeletal proteins aiding in the reorganization of cell structure and enhancing cellular processes like migration.

HAX1 mutations or dysregulation link to severe congenital neutropenia and some neurological disorders. Mutations in HAX1 disrupt the apoptosis inhibition pathway causing a loss in neutrophil count which results in severe congenital neutropenia. This condition is often associated with proteins like ELANE. In some neurological disorders altered HAX1 levels can disturb cellular signaling and survival leading to cellular dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed : 26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed : 26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
See full target information HAX1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 41:1 PubMed34980222

2022

Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Yaxin Chen,Yanzhuo Liu,Yang Wang,Xuewei Chen,Chenlong Wang,Xuehan Chen,Xi Yuan,Lilong Liu,Jing Yang,Xiaoyang Zhou

International journal of molecular medicine 46:1849-1861 PubMed33000203

2020

MicroRNA‑125a‑5p regulates liver cancer cell growth, migration and invasion and EMT by targeting HAX1.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongming Zha,Jie Li

Nature communications 9:1156 PubMed29559685

2018

Redefining the ancestral origins of the interleukin-1 superfamily.

Applications

Unspecified application

Species

Unspecified reactive species

Jack Rivers-Auty,Michael J D Daniels,Isaac Colliver,David L Robertson,David Brough
View all publications
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