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AB234651

Anti-HBLD2 antibody

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(1 Publication)

Rabbit Polyclonal HBLD2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ISCA1 aa 50-150.

View Alternative Names

HBLD2, GK004, ISCA1, HESB-like domain-containing protein 2, Iron-sulfur assembly protein IscA, hIscA

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HBLD2 antibody (AB234651)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HBLD2 antibody (AB234651)

Paraffin-embedded human liver tissue stained for HBLD2 using ab234651 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ISCA1 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q9BUE6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HBLD2 also known as Human Bilayer Domain 2 functions as a lipid-binding protein involved in cell membrane organization. It has a molecular mass of approximately 45 kDa. Researchers commonly observe its expression in liver and muscle tissues although it appears in various other cells to minimal extents. The protein is thought to play a direct role in the stabilization of membrane structures contributing to cellular integrity and function.
Biological function summary

HBLD2 engages in maintaining membrane fluidity and lipid localization. It acts as part of a larger protein complex that regulates the assembly of membrane domains necessary for signal transduction. This role is essential for processes like cellular communication and metabolism. The protein's involvement in organizing lipids shows influence on both the dynamic and structural aspects of membranes indicating its significance in maintaining cellular homeostasis.

Pathways

Involvement of HBLD2 includes the phosphoinositide signaling and fatty acid metabolism pathways. In phosphoinositide signaling HBLD2 interacts with phosphatidylinositol-45-bisphosphate linking it to proteins like PI3K. Through fatty acid metabolism HBLD2 forms relationships with enzymes such as acyl-CoA synthetase. These associations illustrate the protein's position in energy regulation and membrane dynamics important elements of cellular metabolism and signaling.

Abnormal expression or mutations in HBLD2 associates with metabolic disorders and some liver diseases. Changes in HBLD2 levels can disrupt lipid homeostasis leading to metabolic syndrome-related conditions. The protein also links to liver diseases possibly through interactions with liver-specific receptors like LDL receptor. Understanding these associations helps to unravel potential therapeutic targets and interventions in related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
See full target information ISCA1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of biochemical and molecular toxicology 38:e23577 PubMed37934488

2023

Silencing of GDF11 suppresses hepatocyte apoptosis to relieve LPS/D-GalN acute liver failure.

Applications

Unspecified application

Species

Unspecified reactive species

Rongsheng Zhou,Shuang Li,Qun Wang,Yang Bi,Xiaogang Li,Qiang Wang
View all publications
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Product promise

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