AB216844

Anti-HBP1 antibody

Name: Anti-HBP1 antibody (ab216844) | Abcam
Brand: Abcam Limited
SKU: AB216844
Price: 525 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal HBP1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HBP1 aa 450 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

HMG box-containing protein 1, HMG box transcription factor 1, High mobility group box transcription factor 1, HBP1

1 Images

Supplier Data

Western blot - Anti-HBP1 antibody (AB216844)

All lanes:

Western blot - Anti-HBP1 antibody (ab216844) at 1/200 dilution

All lanes:

mouse intestine lysates

Secondary

All lanes:

Goat anti-rabbit IgG antibody (H+L), HRP at 1/3000 dilution

Predicted band size: 58 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

Synthetic Peptide within Human HBP1 aa 450 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O60381

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HBP1 the HMG box-containing protein 1 is a transcriptional repressor with an approximate mass of 55 kDa. It belongs to the high-mobility group (HMG) of proteins characterized by their ability to bind DNA and influence transcription. HBP1 binds directly to DNA sequences acting as a regulator of gene expression. This protein is expressed in various tissues including brain heart and liver.

Biological function summary

HBP1 modulates cell cycle progression and differentiation. It acts as part of a large transcriptional repressor complex influencing the expression of genes involved in these cellular processes. HBP1 has a significant role in repressing genes that drive the cell cycle contributing to control over cell proliferation. In differentiation HBP1 influences the transcription of specific genes that determine cell fate.

Pathways

HBP1 integrates into critical signaling pathways such as the Wnt/beta-catenin and PI3K/Akt pathways. It interacts with beta-catenin potentially hindering its ability to activate transcription of Wnt target genes. This interaction shows HBP1's role in tumor suppression as aberration in these pathways links to oncogenesis. Additionally its involvement in the PI3K/Akt pathway relates to its interaction with other proteins that regulate cell survival and metabolism.

HBP1 has a connection to cancers particularly breast cancer and neurodegenerative diseases like Alzheimer's disease. In breast cancer overexpression of HBP1 may reduce tumor progression by repressing cyclin D1 a protein implicated in cancer cell proliferation. In Alzheimer's altered HBP1 activity could affect neuronal differentiation and survival potentially impacting disease development. Its interactions with proteins like beta-catenin and cyclin D1 provide pathways through which HBP1 may influence these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

See full target information HBP1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of tissue engineering and regenerative medicine 2023:8818561 PubMed40226419

2023

The Effect of Distraction Osteogenesis on Peripheral Nerve Regeneration in Rats: A Preliminary Study .

Applications

Unspecified application

Species

Unspecified reactive species

Kai Liu,Yuanxin Chen,Feiyu Cai,Xin Wang,Chenchen Fan,Peng Ren,Aihemaitijiang Yusufu,Yanshi Liu

Disease markers 2022:5045873 PubMed35845134

2022

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-29a Improves Ovarian Function of Mice with Primary Ovarian Insufficiency by Targeting HMG-Box Transcription Factor/Wnt/-Catenin Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Gao,Yi Cao,Min Hu,Ying Du

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-HBP1 antibody

Western blot - Anti-HBP1 antibody (AB216844)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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