Rabbit Polyclonal GLHA antibody. Suitable for WB and reacts with Recombinant full length protein - Human samples. Cited in 9 publications.
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Publications
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- Scientific reports 13:73872023Mitochondrial citrate metabolism and efflux regulate BeWo differentiation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRenee M Mahr,Snehalata Jena,Sereen K Nashif,Alisa B Nelson,Adam J Rauckhorst,Ferrol I Rome,Ryan D Sheldon,Curtis C Hughey,Patrycja Puchalska,Micah D Gearhart,Eric B Taylor,Peter A Crawford,Sarah A WernimontPubMed 37149697
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34:9419-94322020NPFF increases fusogenic proteins syncytin 1 and syncytin 2 via GCM1 in first trimester primary human cytotrophoblast cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHua Zhu,Bo Peng,Christian Klausen,Yuyin Yi,Yan Li,Siyuan Xiong,Peter von Dadelszen,Peter C K LeungPubMed 32501590
- Analytical and bioanalytical chemistry 411:6837-68452019New photothermal immunoassay of human chorionic gonadotropin using Prussian blue nanoparticle-based photothermal conversion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuolin Hong et. al.PubMed 31471682
- Placenta 39:45-542016Twist1 is involved in trophoblast syncytialization by regulating GCM1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoyin Lu et. al.PubMed 26992674
- Reproduction (Cambridge, England) 149:339-462015Involvement of nephrin in human placental trophoblast syncytialization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYue Li et. al.PubMed 25614620
- Placenta 35:907-182014The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZ Zhou et. al.PubMed 25175744
- Biology of reproduction 90:1172014Live cell imaging of in vitro human trophoblast syncytialization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRui Wang et. al.PubMed 24740598
- Cell death & disease 4:e5932013The proprotein convertase furin is required for trophoblast syncytialization.
- PloS one 7:e525672012Chorionic gonadotropin and its receptor are both expressed in human retina, possible implications in normal and pathological conditions.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
Reactivity data
Select an application| WB | |
|---|---|
| Human | Predicted |
| Recombinant full length protein - Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info 0.5-4 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Associated Products
Select an associated product type
4 products for Alternative Product
Target data
Function
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
Alternative names
Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, Follicle-stimulating hormone alpha chain, Follitropin alpha chain, Luteinizing hormone alpha chain, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, Thyrotropin alpha chain, CG-alpha, FSH-alpha, LSH-alpha, TSH-alpha, CGA
Recommended products
Rabbit Polyclonal GLHA antibody. Suitable for WB and reacts with Recombinant full length protein - Human samples. Cited in 9 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Purification technique
- Affinity purification Protein A
- Specificity
This antibody recognises both alpha and beta subunits of hCG.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 5778 Chorionic Gonadotropin (CG) Antibody. 5778-100 is the same size as the 100 µg size of ab54410.
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of two subunits alpha and beta. The beta subunit confers its specific biological activity. Its molecular weight ranges around 36.7 kDa. hCG is produced in the placenta during pregnancy and is also expressed in pituitary cells. Known alternatively as the pregnancy hormone hCG plays a critical role in maintaining the luteal function during the early stages of pregnancy.
- Biological function summary
HCG regulates several functions related to reproduction. It supports the corpus luteum in ovaries to secrete progesterone during early pregnancy contributing to the uterine lining's maintenance. Moreover hCG can interact with the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) indicating its involvement in broader reproductive functions. Not as well known hCG may exist in various forms such as hCG intact influencing certain biological pathways differently.
- Pathways
Scientists study hCG's role in reproductive signaling and gonadotropin pathways. It interacts closely with luteinizing hormone (LH) with substantial overlap in their pathway functions impacting reproductive health and fertility cycles. hCG's activation of specific receptors like LHCGR plays a role in these pathways connecting it to various fertility-related responses in the human body.
- Associated diseases and disorders
HCG levels can be an indicative marker for certain conditions. Elevated hCG levels may signal trophoblastic diseases such as molar pregnancy or gestational trophoblastic neoplasia. Its abnormal expression might also indicate testicular cancer where it acts as a tumor marker. Both conditions relate to hCG through its shared glycoprotein structure with other hormones like thyroid-stimulating hormone (TSH) which links the hormone to broader endocrine disorder research.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Western blot - Anti-hCG antibody (ab54410)
This information is only intended as a guide. The optimal dilutions must be determined by the user.
All lanes: Western blot - Anti-hCG antibody (ab54410)
Lane 1: Recombinant Human Chorionic Gonadotropin at 0.01 µg
Lane 2: Recombinant Human Chorionic Gonadotropin at 0.05 µg
Lane 3: Recombinant Human Chorionic Gonadotropin at 0.25 µg
Lane 4: Recombinant Human Chorionic Gonadotropin at 1 µg
Predicted band size: 18 kDa
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