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AB238319

Anti-hCG antibody [RM330]

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(4 Publications)

Rabbit Monoclonal GLHA antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CGA.

View Alternative Names

Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, Follicle-stimulating hormone alpha chain, Follitropin alpha chain, Luteinizing hormone alpha chain, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, Thyrotropin alpha chain, CG-alpha, FSH-alpha, LSH-alpha, TSH-alpha, CGA

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG antibody [RM330] (AB238319)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG antibody [RM330] (AB238319)

Formalin-fixed, paraffin-embedded human placenta tissue stained for hGC using ab238319 at 1/1000 dilution in immunohistochemical analysis.

Western blot - Anti-hCG antibody [RM330] (AB238319)
  • WB

Supplier Data

Western blot - Anti-hCG antibody [RM330] (AB238319)

All lanes:

Western blot - Anti-hCG antibody [RM330] (ab238319) at 1/20000 dilution

All lanes:

Native hGC purified from human urine

Predicted band size: 18 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

RM330

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Native Full Length Protein corresponding to Human CGA.

P01215

Specificity

ab238319 reacts to hCG. The antibody recognizes both the native complex and the β subunit of hCG.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/20000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Purified from an animal origin–free culture supernatant.
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of two subunits alpha and beta. The beta subunit confers its specific biological activity. Its molecular weight ranges around 36.7 kDa. hCG is produced in the placenta during pregnancy and is also expressed in pituitary cells. Known alternatively as the pregnancy hormone hCG plays a critical role in maintaining the luteal function during the early stages of pregnancy.
Biological function summary

HCG regulates several functions related to reproduction. It supports the corpus luteum in ovaries to secrete progesterone during early pregnancy contributing to the uterine lining's maintenance. Moreover hCG can interact with the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) indicating its involvement in broader reproductive functions. Not as well known hCG may exist in various forms such as hCG intact influencing certain biological pathways differently.

Pathways

Scientists study hCG's role in reproductive signaling and gonadotropin pathways. It interacts closely with luteinizing hormone (LH) with substantial overlap in their pathway functions impacting reproductive health and fertility cycles. hCG's activation of specific receptors like LHCGR plays a role in these pathways connecting it to various fertility-related responses in the human body.

HCG levels can be an indicative marker for certain conditions. Elevated hCG levels may signal trophoblastic diseases such as molar pregnancy or gestational trophoblastic neoplasia. Its abnormal expression might also indicate testicular cancer where it acts as a tumor marker. Both conditions relate to hCG through its shared glycoprotein structure with other hormones like thyroid-stimulating hormone (TSH) which links the hormone to broader endocrine disorder research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
See full target information CGA
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of cachexia, sarcopenia and muscle 16:e13734 PubMed39971710

2025

SIRT6 Ameliorates Cancer Cachexia-Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Kang Xu,Yida Wang,Fang Wang,Yannan Guo,Yu Ren,Vivien Low,Sungyun Cho,Qingfei Liu,Ying Qiu,Xue Li,Kang Yu,Zhongchi Li,Zhao Wang

Heliyon 10:e24499 PubMed38298727

2024

CPY27B1-related vitamin D deficiency contributes to the impaired function of CD4T cells in Recurrent spontaneous miscarriage.

Applications

Unspecified application

Species

Unspecified reactive species

Chaoyan Yue,Yanhui Ma,Mingyan Wang,Minmin Yuan,Yi Meng,Zhiheng Wang,Chunmei Ying

Frontiers in cell and developmental biology 11:1167097 PubMed37250894

2023

Metformin impairs trophoblast metabolism and differentiation in a dose-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Sereen K Nashif,Renee M Mahr,Snehalata Jena,Seokwon Jo,Alisa B Nelson,Danielle Sadowski,Peter A Crawford,Patrycja Puchalska,Emilyn U Alejandro,Micah D Gearhart,Sarah A Wernimont

Scientific reports 13:7387 PubMed37149697

2023

Mitochondrial citrate metabolism and efflux regulate BeWo differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Renee M Mahr,Snehalata Jena,Sereen K Nashif,Alisa B Nelson,Adam J Rauckhorst,Ferrol I Rome,Ryan D Sheldon,Curtis C Hughey,Patrycja Puchalska,Micah D Gearhart,Eric B Taylor,Peter A Crawford,Sarah A Wernimont
View all publications
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