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AB11392

Anti-hCG Holo c2 antibody [INN-hCG-53]

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(1 Publication)

Mouse Monoclonal GLHA antibody. Suitable for ELISA, WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, Follicle-stimulating hormone alpha chain, Follitropin alpha chain, Luteinizing hormone alpha chain, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, Thyrotropin alpha chain, CG-alpha, FSH-alpha, LSH-alpha, TSH-alpha, CGA

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

INN-hCG-53

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ELISA

applications

Specificity

Ab11392 recognises epitope c2 on hCG. It does not recognise free hCG subunits.

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Reactivity data

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Product details

This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The hCG Holo c2 also known as human chorionic gonadotropin is a glycoprotein hormone with a molecular mass of approximately 36.7 kDa. This protein is synthesized and secreted by the placenta specifically by the syncytiotrophoblasts during pregnancy. It consists of two subunits: alpha and beta with the beta subunit being unique to hCG. The expression of hCG Holo c2 plays a pivotal role in the early stages of pregnancy by maintaining the corpus luteum and facilitating progesterone production.
Biological function summary

HCG Holo c2 stimulates hormonal support during pregnancy. It works as part of a complex multi-hormonal system where it binds to the LH/CG receptor on the corpus luteum. This binding ensures the production of progesterone sustaining the uterine lining for embryo implantation and preventing menstruation. The action of hCG mimics that of luteinizing hormone (LH) although its prolonged action makes it particularly effective during pregnancy.

Pathways

It actively participates in the reproductive hormone signaling pathway interacting with the LH/CG receptor which is shared with luteinizing hormone. It is also important in the cyclic AMP-dependent signaling pathway connected through its action on adenylate cyclase which elevates cyclic AMP levels upon receptor binding. These pathways highlight its association with proteins like progesterone.

Elevated levels may indicate gestational trophoblastic disease such as hydatidiform mole and choriocarcinoma. Also abnormal production or expression of hCG plays a role in certain types of testicular cancer. Proteins such as alpha-fetoprotein (AFP) and placental alkaline phosphatase in combination with hCG serve as biomarkers for these conditions and manage patient monitoring and treatment planning.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
See full target information CGA
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 6:36075 PubMed27824055

2016

Involvement of eIF6 in external mechanical stretch-mediated murine dermal fibroblast function via TGF-β1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qin Shu,Jianglin Tan,Van Daele Ulrike,Xiaorong Zhang,Jiacai Yang,Sisi Yang,Xiaohong Hu,Weifeng He,Gaoxing Luo,Jun Wu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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