JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB11393

Anti-hCG Holo c3 antibody [INN-hCG-45]

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Monoclonal GLHA antibody. Suitable for ELISA, RIA and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, Follicle-stimulating hormone alpha chain, Follitropin alpha chain, Luteinizing hormone alpha chain, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, Thyrotropin alpha chain, CG-alpha, FSH-alpha, LSH-alpha, TSH-alpha, CGA

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

INN-hCG-45

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

ELISA, RIA

applications

Specificity

ab11393 reacts with holo hCG recognising the c3 epitope on hCG. No subunit detection is observed. Suitable for use as a capture antibody.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }
style
left-column

Product details

This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Purified IgG prepared by ion exchange.
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HCG Holo c3 also known as Human Chorionic Gonadotropin Holo Core 3 is a glycoprotein hormone with a mass of approximately 37 kDa. It consists of an alpha subunit and a beta subunit which form a dimeric structure. The target is widely expressed in the placenta and is secreted during pregnancy. This hormone plays a critical role in maintaining the corpus luteum which is essential for sustaining early pregnancy. It also interacts with the luteinizing hormone/chorionic gonadotropin receptor.
Biological function summary

The hCG hormone is important for reproductive physiology. It supports fetal development by promoting angiogenesis and modulating the immune response. As part of the larger glycoprotein hormone family it shares structural similarities with other glycoproteins like LH FSH and TSH. These proteins form a complex influencing various biological processes by binding to their respective receptors.

Pathways

The hCG Holo c3 participates in the reproductive hormonal signaling pathway that regulates reproductive function. It is involved in the pregnancy pathway where it interacts with several proteins including steroidogenic acute regulatory protein (StAR) and aromatase. These interactions help regulate the production of progesterone and other steroid hormones necessary for maintaining pregnancy.

Abnormal levels of hCG Holo c3 have associations with trophoblastic diseases and certain types of cancer such as choriocarcinoma. Its levels serve as biomarkers for pregnancy tests and monitoring some cancers. The hCG hormone relates to disorders involving abnormal pregnancy such as ectopic pregnancy. Additionally it connects to the luteinizing hormone through its shared receptor pathway highlighting its role in reproductive and endocrine health.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
See full target information CGA
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 6:36075 PubMed27824055

2016

Involvement of eIF6 in external mechanical stretch-mediated murine dermal fibroblast function via TGF-β1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qin Shu,Jianglin Tan,Van Daele Ulrike,Xiaorong Zhang,Jiacai Yang,Sisi Yang,Xiaohong Hu,Weifeng He,Gaoxing Luo,Jun Wu
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB11392

Anti-hCG Holo c2 antibody [INN-hCG-53]

  • 0
  • 0
Primary Antibodies

AB214337

Anti-Flavivirus NS1 antibody [D/2/D6/B7]

Immunocytochemistry/ Immunofluorescence - Anti-Flavivirus NS1 antibody [D/2/D6/B7] (AB214337)

  • 0
  • 0
Primary Antibodies

AB273169

HRP Anti-SARS-CoV-2 spike glycoprotein antibody [H6] - Mouse IgG1 (Chimeric)

Recombinant

ELISA - HRP Anti-SARS-CoV-2 spike glycoprotein antibody [H6] - Mouse IgG1 (Chimeric) (AB273169)

  • 0
  • 0
Primary Antibodies

AB41621

Anti-EAAT2 antibody

Western blot - Anti-EAAT2 antibody (AB41621)

  • 4
  • 6

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com