Rabbit Polyclonal hCG receptor/LHR antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 3 publications.
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- Cells 12:2023Rat Ovarian Function Is Impaired during Experimental Autoimmune Encephalomyelitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAna Milosevic,Irena Lavrnja,Danijela Savic,Katarina Milosevic,Jelena Skuljec,Ivana Bjelobaba,Marija M JanjicPubMed 37048118
- American journal of physiology. Regulatory, integr 312:R569-R5742017Seasonal expressions of follicle-stimulating hormone receptor and luteinizing hormone receptor in the scented gland of the male muskrat ().Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaolin Zhang et. al.PubMed 28228419
- Fertility and sterility 104:474-822015Human chorionic gonadotropin stimulates spheroid attachment on fallopian tube epithelial cells through the mitogen-activated protein kinase pathway and down-regulation of olfactomedin-1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKam-Hei So et. al.PubMed 25999259
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Expected |
| Rat | Expected | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.10000-0.50000 µg/mL | Notes The detection limit for ab125214 is approximately 0.1ng/lane under non-reducing and reducing conditions. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.50000-1.00000 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).
Alternative names
LCGR, LGR2, LHRHR, LHCGR, Lutropin-choriogonadotropic hormone receptor, LH/CG-R, Luteinizing hormone receptor, LHR, LSH-R
Recommended products
Rabbit Polyclonal hCG receptor/LHR antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 3 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The hCG receptor also known as LHR LHCGR or LH/CG receptor belongs to the G-protein coupled receptor family and is essential for reproductive processes. It has a mass of around 85 kDa and it is expressed mostly in the ovaries and testes. The receptor binds to the hCG protein also referred to as human chorionic gonadotropin and LH luteinizing hormone. Both the hCG protein and the hCG peptide stimulate the receptor leading to various reproductive functions. The anti-LHR antibodies target this receptor specifically allowing for detailed study and potential clinical applications.
- Biological function summary
The hCG receptor plays a significant role in mediating reproductive hormone signaling. As part of a complex with the hCG protein it facilitates the regulation of steroidogenesis and gametogenesis. In females the activation of LHR by the hCG hormone results in the maintenance of the corpus luteum important for progesterone production in early pregnancy. Meanwhile in males LHR influences testosterone production by Leydig cells impacting spermatogenesis significantly.
- Pathways
The hCG receptor significantly affects reproductive endocrine pathways that include the cAMP/PKA signaling pathway. Through this pathway the receptor interacts with several related proteins such as adenylate cyclase which further activates cAMP production. The activation of protein kinase A (PKA) facilitates downstream signaling events essential in the ovulation and spermatogenesis processes. The synergy between the hCG receptor and these pathways underlines its biological significance.
- Associated diseases and disorders
The hCG receptor is associated with reproductive health issues like infertility and polycystic ovary syndrome (PCOS). Dysregulation or mutations in LHR can disrupt normal reproductive functions and lead to these disorders. The receptor's interaction with proteins such as FSH receptor (FSHR) further influences the manifestation of these conditions making it a target for therapeutic interventions in reproductive medicine both in clinics and private labs in various places including hCG-focused research in Mexico.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG receptor/LHR antibody (ab125214)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) staining hCG receptor/LHR in Rat Ovary Tissue.
Western blot - Anti-hCG receptor/LHR antibody (ab125214)
All lanes: Western blot - Anti-hCG receptor/LHR antibody (ab125214) at 0.5 µg/mL
All lanes: MCF-7 Whole Cell Lysate at 40 µg
Predicted band size: 79 kDa
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