AB125214

Anti-hCG receptor/LHR antibody

Name: Anti-hCG receptor/LHR antibody (ab125214) | Abcam
Brand: Abcam Limited
SKU: AB125214

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(9 Publications)

Rabbit Polyclonal hCG receptor/LHR antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 9 publications.

View Alternative Names

LCGR, LGR2, LHRHR, LHCGR, Lutropin-choriogonadotropic hormone receptor, LH/CG-R, Luteinizing hormone receptor, LHR, LSH-R

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG receptor/LHR antibody (AB125214)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG receptor/LHR antibody (AB125214)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) staining hCG receptor/LHR in Rat Ovary Tissue.

Supplier Data

Western blot - Anti-hCG receptor/LHR antibody (AB125214)

All lanes:

Western blot - Anti-hCG receptor/LHR antibody (ab125214) at 0.5 µg/mL

All lanes:

MCF-7 Whole Cell Lysate at 40 µg

Predicted band size: 79 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p>The detection limit for ab125214 is approximately 0.1ng/lane under non-reducing and reducing conditions.</p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The hCG receptor also known as LHR LHCGR or LH/CG receptor belongs to the G-protein coupled receptor family and is essential for reproductive processes. It has a mass of around 85 kDa and it is expressed mostly in the ovaries and testes. The receptor binds to the hCG protein also referred to as human chorionic gonadotropin and LH luteinizing hormone. Both the hCG protein and the hCG peptide stimulate the receptor leading to various reproductive functions. The anti-LHR antibodies target this receptor specifically allowing for detailed study and potential clinical applications.

Biological function summary

The hCG receptor plays a significant role in mediating reproductive hormone signaling. As part of a complex with the hCG protein it facilitates the regulation of steroidogenesis and gametogenesis. In females the activation of LHR by the hCG hormone results in the maintenance of the corpus luteum important for progesterone production in early pregnancy. Meanwhile in males LHR influences testosterone production by Leydig cells impacting spermatogenesis significantly.

Pathways

The hCG receptor significantly affects reproductive endocrine pathways that include the cAMP/PKA signaling pathway. Through this pathway the receptor interacts with several related proteins such as adenylate cyclase which further activates cAMP production. The activation of protein kinase A (PKA) facilitates downstream signaling events essential in the ovulation and spermatogenesis processes. The synergy between the hCG receptor and these pathways underlines its biological significance.

The hCG receptor is associated with reproductive health issues like infertility and polycystic ovary syndrome (PCOS). Dysregulation or mutations in LHR can disrupt normal reproductive functions and lead to these disorders. The receptor's interaction with proteins such as FSH receptor (FSHR) further influences the manifestation of these conditions making it a target for therapeutic interventions in reproductive medicine both in clinics and private labs in various places including hCG-focused research in Mexico.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for lutropin-choriogonadotropic hormone (PubMed : 11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed : 11847099).

See full target information LHCGR

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Cells 13: PubMed39451222

2024

Decreased Circulating Gonadotropin-Releasing Hormone Associated with Keratoconus.

Applications

Unspecified application

Species

Unspecified reactive species

Paulina Escandon,Alexander J Choi,Steve Mabry,Sarah E Nicholas,Rebecca L Cunningham,Liam Redden,David A Murphy,Kamran M Riaz,Tina B McKay,Dimitrios Karamichos

Experimental & molecular medicine 56:1591-1605 PubMed38945952

2024

Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Se-Ra Park,Myung Geun Kook,Soo-Rim Kim,Choon-Mi Lee,Jin Woo Lee,Jung-Kyu Park,Chan Hum Park,Byung-Chul Oh,YunJae Jung,In-Sun Hong

International journal of molecular sciences 24: PubMed37686439

2023

Novel Correlation between TGF-β1/-β3 and Hormone Receptors in the Human Corneal Stroma.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander J Choi,Brenna S Hefley,Sarah E Nicholas,Rebecca L Cunningham,Dimitrios Karamichos

Environmental health perspectives 131:67010 PubMed37342990

2023

Effects of Cyanobacterial Harmful Algal Bloom Toxin Microcystin-LR on Gonadotropin-Dependent Ovarian Follicle Maturation and Ovulation in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yingzheng Wang,Pawat Pattarawat,Jiyang Zhang,Eunchong Kim,Delong Zhang,Mingzhu Fang,Elizabeth A Jannaman,Ye Yuan,Saurabh Chatterjee,Ji-Yong Julie Kim,Geoffrey I Scott,Qiang Zhang,Shuo Xiao

Cells 12: PubMed37048118

2023

Rat Ovarian Function Is Impaired during Experimental Autoimmune Encephalomyelitis.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Milosevic,Irena Lavrnja,Danijela Savic,Katarina Milosevic,Jelena Skuljec,Ivana Bjelobaba,Marija M Janjic

The American journal of pathology 193:1762-1775 PubMed36822267

2023

Selective Modulation of the Keratoconic Stromal Microenvironment by FSH and LH.

Applications

Unspecified application

Species

Unspecified reactive species

Paulina Escandon,Sarah E Nicholas,Brenda Vasini,Rebecca L Cunningham,David A Murphy,Kamran M Riaz,Dimitrios Karamichos

Journal of ovarian research 15:129 PubMed36476625

2022

Luteinizing hormone stimulates the expression of amphiregulin in human theca cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Liu,Yiping Zhong,Xiaoting Shen,Xi Guo,Rihan Wu,Turui Yang,Minghui Chen

American journal of physiology. Regulatory, integr 312:R569-R574 PubMed28228419

2017

Seasonal expressions of follicle-stimulating hormone receptor and luteinizing hormone receptor in the scented gland of the male muskrat ().

Applications

Unspecified application

Species

Unspecified reactive species

Haolin Zhang,Fengwei Zhang,Manyu Zhu,Junjie Wang,Xia Sheng,Zhengrong Yuan,Yingying Han,Gen Watanabe,Kazuyoshi Taya,Qiang Weng

Fertility and sterility 104:474-82 PubMed25999259

2015

Human chorionic gonadotropin stimulates spheroid attachment on fallopian tube epithelial cells through the mitogen-activated protein kinase pathway and down-regulation of olfactomedin-1.

Applications

Unspecified application

Species

Unspecified reactive species

Kam-Hei So,Suranga P Kodithuwakku,Kottawattage S A Kottawatta,Raymond H W Li,Philip C N Chiu,Annie N Y Cheung,Ernest H Y Ng,William S B Yeung,Kai-Fai Lee

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-hCG receptor/LHR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG receptor/LHR antibody (AB125214)

Western blot - Anti-hCG receptor/LHR antibody (AB125214)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise