Mouse Monoclonal hCG receptor/LHR antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LHCGR aa 50-450.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG receptor/LHR antibody [LHCGR/1417] - BSA and Azide free (AB218907), expandable thumbnail](https://content.abcam.com/products/images/hcg-receptor-lhr-antibody-lhcgr-1417-bsa-and-azide-free-ab218907--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img123456.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG receptor/LHR antibody [LHCGR/1417] - BSA and Azide free (AB218907)")
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.2 - 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Fragment Protein within Human LHCGR aa 50-450. The exact immunogen used to generate this antibody is proprietary information. Database link P22888
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.5-1 µg/mL | Notes (Primary incubation for 30 minutes at RT). Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).
Alternative names
LCGR, LGR2, LHRHR, LHCGR, Lutropin-choriogonadotropic hormone receptor, LH/CG-R, Luteinizing hormone receptor, LHR, LSH-R
Recommended products
Mouse Monoclonal hCG receptor/LHR antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LHCGR aa 50-450.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.2 - 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Fragment Protein within Human LHCGR aa 50-450. The exact immunogen used to generate this antibody is proprietary information. Database link P22888
- Carrier free
- Yes
- Clone number
- LHCGR/1417
- Purification technique
- Affinity purification Protein G
- Light chain type
- kappa
- Concentration
- Purification notes
ab218907 was purified from Bioreactor Concentrate by Protein A/G.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The hCG receptor also known as LHR LHCGR or LH/CG receptor belongs to the G-protein coupled receptor family and is essential for reproductive processes. It has a mass of around 85 kDa and it is expressed mostly in the ovaries and testes. The receptor binds to the hCG protein also referred to as human chorionic gonadotropin and LH luteinizing hormone. Both the hCG protein and the hCG peptide stimulate the receptor leading to various reproductive functions. The anti-LHR antibodies target this receptor specifically allowing for detailed study and potential clinical applications.
- Biological function summary
The hCG receptor plays a significant role in mediating reproductive hormone signaling. As part of a complex with the hCG protein it facilitates the regulation of steroidogenesis and gametogenesis. In females the activation of LHR by the hCG hormone results in the maintenance of the corpus luteum important for progesterone production in early pregnancy. Meanwhile in males LHR influences testosterone production by Leydig cells impacting spermatogenesis significantly.
- Pathways
The hCG receptor significantly affects reproductive endocrine pathways that include the cAMP/PKA signaling pathway. Through this pathway the receptor interacts with several related proteins such as adenylate cyclase which further activates cAMP production. The activation of protein kinase A (PKA) facilitates downstream signaling events essential in the ovulation and spermatogenesis processes. The synergy between the hCG receptor and these pathways underlines its biological significance.
- Associated diseases and disorders
The hCG receptor is associated with reproductive health issues like infertility and polycystic ovary syndrome (PCOS). Dysregulation or mutations in LHR can disrupt normal reproductive functions and lead to these disorders. The receptor's interaction with proteins such as FSH receptor (FSHR) further influences the manifestation of these conditions making it a target for therapeutic interventions in reproductive medicine both in clinics and private labs in various places including hCG-focused research in Mexico.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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1 product image
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG receptor/LHR antibody [LHCGR/1417] - BSA and Azide free (ab218907), expandable thumbnail](https://content.abcam.com/products/images/hcg-receptor-lhr-antibody-lhcgr-1417-bsa-and-azide-free-ab218907--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img123456.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG receptor/LHR antibody [LHCGR/1417] - BSA and Azide free (ab218907)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hCG receptor/LHR antibody [LHCGR/1417] - BSA and Azide free (ab218907)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human ovarian carcinoma tissue labeling hCG receptor/LHR with ab218907 at 1 μg/ml.
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