Anti-HCoV-229E Nucleocapsid protein antibody [abd210] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The HCoV-229E Nucleocapsid protein also known as the N protein plays a mechanical role within the human coronavirus 229E (HCoV-229E). This protein has a mass of around 45 kDa and is expressed in the cytoplasm of infected host cells. Its primary function lies in binding to the viral RNA genome forming a ribonucleoprotein complex that protects the RNA and contributes to the stability of the viral genome. The HCoV-229E nucleocapsid protein is important for the correct assembly and packaging of the viral RNA into new virions.

Biological function summary

The N protein directly impacts viral replication and transcription. It forms part of a larger ribonucleoprotein complex that organizes the viral genome into a functional and protected structure. This complex interacts with other viral proteins to facilitate the replication process. The N protein also boosts the efficiency of the viral RdRp (RNA-dependent RNA polymerase) in transcribing the RNA genome ensuring that viral replication proceeds efficiently and effectively within host cells.

Pathways

The N protein integrates into the coronavirus replication-transcription complex. It coordinates with the viral RdRp and other non-structural proteins of the virus to ensure a streamlined replication process. This protein interacts with cellular pathways that include stress response and immune pathways potentially modulating host immune responses to benefit viral survival and replication. These interactions with host cell pathways may influence the efficiency of viral replication and the pathogenicity of the virus.

Associated diseases and disorders

HCoV-229E Nucleocapsid protein connects to common cold manifestations and in some cases exacerbates chronic respiratory disorders. The N protein’s interactions with other viral proteins like the Spike protein might enhance viral entry and infectivity which could contribute to varying severity of infection. Understanding the role of the N protein in these contexts is important for developing therapeutic strategies and improving disease management for infections caused by HCoV-229E.