JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB1767

Anti-HDAC1 antibody - Nuclear Loading Control and ChIP Grade

Be the first to review this product! Submit a review

|

(21 Publications)

Rabbit Polyclonal HDAC1 antibody. Suitable for IP, ChIP, WB, ICC/IF, IHC - Wmt and reacts with Drosophila melanogaster samples. Cited in 21 publications. Immunogen corresponding to Synthetic Peptide within Drosophila melanogaster HDAC1 aa 500 to C-terminus.

View Alternative Names

Rpd3, CG7471, HDAC1, Histone deacetylase HDAC1, HD

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Drosophila melanogaster

Applications

IP, WB, ChIP, ICC/IF, IHC - Wmt

applications

Immunogen

Synthetic Peptide within Drosophila melanogaster HDAC1 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q94517

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ChIP" : {"fullname" : "ChIP", "shortname":"ChIP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCWmt" : {"fullname" : "IHC - Wholemount", "shortname":"IHC - Wmt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Drosophila melanogaster": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "ChIP-species-checked": "guaranteed", "ChIP-species-dilution-info": "", "ChIP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCWmt-species-checked": "guaranteed", "IHCWmt-species-dilution-info": "", "IHCWmt-species-notes": "<p></p>" } } }
style
left-column

Product details

The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels.
style
left-column

Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.02% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HDAC1 also known as Histone Deacetylase 1 is a member of the histone deacetylase family with a molecular weight of approximately 55 kDa. Mechanically HDAC1 removes acetyl groups from lysine residues on histone proteins an action known as histone deacetylation. This process causes chromatin structure to become more compact which leads to transcriptional repression. HDAC1 is broadly expressed in various tissues particularly in the brain heart and kidneys and is vital for cellular development and differentiation.
Biological function summary

The enzymatic activity of histone deacetylase effectively controls gene expression. HDAC1 participates as a part of the multiprotein complexes including SIN3 and NuRD which play vital roles in the regulation of transcription. By altering the acetylation state of histones HDAC1 influences chromatin remodeling thereby affecting the accessibility of transcription factors to DNA and controlling genes necessary for cell cycle progression and proliferation.

Pathways

The function of HDAC1 fits into the regulation of the cell cycle and apoptosis pathways. In the cell cycle pathway HDAC1 interacts with other histone deacetylases (HDACs) and plays a role in controlling the progression of the cell division. The interplay between HDAC1 and proteins such as p53 further showcases its regulatory activity in apoptosis ensuring cell survival or programmed cell death when necessary.

HDAC1 shows significant relevance to cancer and neurodegenerative diseases. In cancer the overexpression or abnormal regulation of HDAC1 can lead to uncontrolled cell proliferation often linked to the silencing of tumor suppressor genes. Within neurodegenerative conditions HDAC1-related disturbances in gene expression may result in impaired neuronal function and survival. The involvement of HDAC1 with proteins such as p53 and other HDACs illustrates its impact on complex disease mechanisms making it a critical target for therapeutic interventions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed : 11571273, PubMed : 12408863, PubMed : 28245922). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed : 11571273, PubMed : 15306652, PubMed : 15545624, PubMed : 8955276). For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones (PubMed : 11571273). Involved in position-effect variegation (PEV) (PubMed : 11571273). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP) (PubMed : 28245922).
See full target information HDAC1
style
left-column

Publications (21)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:7930 PubMed40855028

2025

Dual mitotic bookmarking by GAF and H3K27ac orchestrates differential propagation of cell fate memory in neural development.

Applications

Unspecified application

Species

Unspecified reactive species

Rulan Zhang,Jie Liu,Zimo Zhang,Zili Chen,Tanpeng Wang,Yuying Shen,Zejun Lan,Jingyi Chu,Haoxuan Tang,Xiyue Zhang,Yan Song

Nucleic acids research 52:5698-5719 PubMed38587186

2024

ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response.

Applications

Unspecified application

Species

Unspecified reactive species

Ali Bakr,Giuditta Della Corte,Olivera Veselinov,Simge Kelekçi,Mei-Ju May Chen,Yu-Yu Lin,Gianluca Sigismondo,Marika Iacovone,Alice Cross,Rabail Syed,Yunhee Jeong,Etienne Sollier,Chun-Shan Liu,Pavlo Lutsik,Jeroen Krijgsveld,Dieter Weichenhan,Christoph Plass,Odilia Popanda,Peter Schmezer

Briefings in bioinformatics 24: PubMed36759336

2023

HiConfidence: a novel approach uncovering the biological signal in Hi-C data affected by technical biases.

Applications

Unspecified application

Species

Unspecified reactive species

Victoria A Kobets,Sergey V Ulianov,Aleksandra A Galitsyna,Semen A Doronin,Elena A Mikhaleva,Mikhail S Gelfand,Yuri Y Shevelyov,Sergey V Razin,Ekaterina E Khrameeva

Nucleic acids research 50:11529-11549 PubMed36330957

2022

eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenxing Song,Jiamei Lin,Rui Su,Yu Ji,Ruirui Jia,Shi Li,Ge Shan,Chuan Huang

Epigenetics 17:786-807 PubMed34369292

2021

Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain.

Applications

Unspecified application

Species

Unspecified reactive species

Mariah Beaver,Bhanu Chandra Karisetty,Haolin Zhang,Akanksha Bhatnagar,Ellen Armour,Visha Parmar,Reshma Brown,Merry Xiang,Felice Elefant

Nucleic acids research 49:6296-6314 PubMed34107019

2021

Gawky modulates MTF-1-mediated transcription activation and metal discrimination.

Applications

Unspecified application

Species

Unspecified reactive species

Ruirui Jia,Zhenxing Song,Jiamei Lin,Zhengguo Li,Ge Shan,Chuan Huang

Molecular and cellular neurosciences 109:103570 PubMed33160016

2020

Tip60 protects against amyloid-β-induced transcriptomic alterations via different modes of action in early versus late stages of neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Haolin Zhang,Bhanu Chandra Karisetty,Akanksha Bhatnagar,Ellen M Armour,Mariah Beaver,Tiffany V Roach,Sina Mortazavi,Shreya Mandloi,Felice Elefant

Scientific reports 10:18265 PubMed33106538

2020

Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Mariah Beaver,Akanksha Bhatnagar,Priyalakshmi Panikker,Haolin Zhang,Renee Snook,Visha Parmar,Gayathri Vijayakumar,Niteesha Betini,Sunya Akhter,Felice Elefant

The Journal of neuroscience : the official journal 38:4569-4583 PubMed29654189

2018

Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition.

Applications

Unspecified application

Species

Unspecified reactive species

Priyalakshmi Panikker,Song-Jun Xu,Haolin Zhang,Jessica Sarthi,Mariah Beaver,Avni Sheth,Sunya Akhter,Felice Elefant

Epigenetics 11:303-19 PubMed27019326

2016

Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis.

Applications

Unspecified application

Species

Unspecified reactive species

Alejandro Cabezas-Cruz,Pilar Alberdi,Nieves Ayllón,James J Valdés,Raymond Pierce,Margarita Villar,José de la Fuente
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB109411

Anti-HDAC1 antibody [EPR460(2)] - Nuclear Loading Control

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-HDAC1 antibody [EPR460(2)] - Nuclear Loading Control (AB109411)

  • 4
  • 6
Primary Antibodies

AB68436

Anti-HDAC1 antibody [mAbcam 68436] - Nuclear Loading Control

Western blot - Anti-HDAC1 antibody [mAbcam 68436] - Nuclear Loading Control (AB68436)

  • 0
  • 1
Primary Antibodies

AB19845

Anti-HDAC1 antibody - Nuclear Loading Control

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-HDAC1 antibody - Nuclear Loading Control (AB19845)

  • 4
  • 9
Primary Antibodies

AB192469

Alexa Fluor® 488 Anti-HDAC1 antibody [EPR460(2)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-HDAC1 antibody [EPR460(2)] (AB192469)

  • 0
  • 0
Primary Antibodies

AB192470

Alexa Fluor® 647 Anti-HDAC1 antibody [EPR460(2)]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-HDAC1 antibody [EPR460(2)] (AB192470)

  • 0
  • 0
Primary Antibodies

AB150399

Anti-HDAC1 antibody [EPR5517(2)] - Nuclear Loading Control

RabMAb|Advanced Validation|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-HDAC1 antibody [EPR5517(2)] - Nuclear Loading Control (AB150399)

  • 1
  • 1
Primary Antibodies

AB213701

Anti-HDAC1 antibody [EPR460(2)] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-HDAC1 antibody [EPR460(2)] - BSA and Azide free (AB213701)

  • 4
  • 1

Complementary Products

Primary Antibodies

AB32117

Anti-HDAC2 antibody [Y461]

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HDAC2 antibody [Y461] (AB32117)

  • 5
  • 12
Primary Antibodies

AB1791

Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade

Lab Essentials

ChIP - Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade (AB1791)

  • 5
  • 233
Primary Antibodies

AB32369

Anti-HDAC3 antibody [Y415]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HDAC3 antibody [Y415] (AB32369)

  • 5
  • 6
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com