AB18971

Anti-HDAC10 antibody

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(4 Publications)

Rabbit Polyclonal HDAC10 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human HDAC10.

View Alternative Names

Polyamine deacetylase HDAC10, Histone deacetylase 10, HD10, HDAC10

1 Images

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Western blot - Anti-HDAC10 antibody (AB18971)

All lanes:

Western blot - Anti-HDAC10 antibody (ab18971) at 2.5 µg/mL

Lane 1:

Jurkat cell lysate (30ug)

Lane 2:

Mouse intestine lysate (30ug)

Lane 3:

Rat brain lysate (30ug)

Predicted band size: 71 kDa

Observed band size: 55 kDa,74 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

applications

Immunogen

Synthetic Peptide within Human HDAC10. The exact immunogen used to generate this antibody is proprietary information.

Q969S8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-4 µg/mL", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-4 µg/mL", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-4 µg/mL", "WB-species-notes": "" } } }

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 3610 HDAC10 Antibody. 3610-100 is the same size as the 100 µg size of ab18971.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.02% Thimerosal (merthiolate) Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HDAC10 also known as Histone Deacetylase 10 is an enzyme belonging to the HDAC family instrumental in removing acetyl groups from histone proteins and other non-histone proteins. This protein around 71 kDa in mass influences chromatin structure and regulates gene transcription. HDAC10 is expressed in various tissues including the kidney and liver and plays a direct role in the modulation of gene expression through its deacetylase activity impacting cellular processes and environmental responses.

Biological function summary

HDAC10 functions as a regulatory component within the cellular milieu influencing transcriptional repression across several pathways. HDAC10 often forms part of multi-protein complexes although not extensively characterized they include other HDAC family members. It participates in controlling cell growth and cell cycle progress and shows involvement in DNA repair mechanisms. By modulating gene expression through deacetylation HDAC10 impacts cellular proliferation and differentiation.

Pathways

HDAC10 plays a role in the PI3K/AKT signaling pathway which is important for cell survival and growth. HDAC10 interacts with proteins like AKT1 assisting with the transduction of the signaling cascade that contributes to cell cycle progression and apoptosis regulation. Also this enzyme interplays with the autophagy pathway influencing cellular metabolism and homeostasis through its deacetylation functions impacting Beclin-1 regulation and activity levels.

HDAC10 has been implicated in cancer and neurodegenerative diseases. In cancer particularly renal carcinoma HDAC10 may alter oncogene expression and tumor-suppressor levels connecting with proteins such as p53 which are vital in cell-cycle regulation and apoptosis. In neurodegenerative disorders modulations in HDAC10 levels affect huntingtin protein acetylation impacting the progression of diseases like Huntington's disease. Its role in histone and non-histone protein regulation positions HDAC10 as a potential target for therapeutic interventions in these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed : 28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed : 28516954). Histone deacetylase activity has been observed in vitro (PubMed : 11677242, PubMed : 11726666, PubMed : 11739383, PubMed : 11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed : 26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed : 28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed : 23801752, PubMed : 29968769). May play a role in homologous recombination (PubMed : 21247901). May promote DNA mismatch repair (PubMed : 26221039).

See full target information HDAC10

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Mediators of inflammation 2025:8156593 PubMed40151316

2025

The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation.

Applications

Unspecified application

Species

Unspecified reactive species

Chenyu Zhang,Hongyan Wei,Qiang Zhang,Haohong Zhan,Yuanzheng Lu,Yujie Li,Bo Li,Wen Huang,Feng Nian,Rong Liu,Chunlin Hu,Jie Chen

Nucleic acids research 52:11785-11805 PubMed39291733

2024

Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sangin Kim,Su Hyung Park,Nalae Kang,Jae Sun Ra,Kyungjae Myung,Kyoo-Young Lee

Pharmacological research 146:104281 PubMed31125601

2019

Histone deacetylase 6 inhibitor tubastatin A attenuates angiotensin II-induced hypertension by preventing cystathionine γ-lyase protein degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhexi Chi,Hye-Eun Byeon,Eunjeong Seo,Quynh-Anh T Nguyen,Wonbeom Lee,Yunyong Jeong,Juyong Choi,Deepesh Pandey,Dan E Berkowitz,Jae Hyung Kim,Sang Yoon Lee

Journal of translational medicine 14:7 PubMed26747087

2016

Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells.

Applications

Unspecified application

Species

Human

Jiaqi Liu,Jianying Gu,Zihao Feng,Yanhong Yang,Ningwen Zhu,Weiyue Lu,Fazhi Qi

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HDAC10 antibody

Western blot - Anti-HDAC10 antibody (AB18971)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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