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AB157595

Anti-HDL antibody

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(1 Publication)

Chicken Polyclonal Apolipoprotein A I antibody. Suitable for ELISA, RIA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human APOA1.

View Alternative Names

Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, APOA1

Key facts

Host species

Chicken

Clonality

Polyclonal

Isotype

IgY

Carrier free

No

Reacts with

Human

Applications

ELISA, RIA

applications

Immunogen

Native Full Length Protein corresponding to Human APOA1.

P02647

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Alternative Products

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AB157416

Biotin Anti-HDL antibody

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Complementary Products

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Primary Antibodies

AB109324

Anti-HDLBP antibody [EPR5267]

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Primary Antibodies

AB52945

Anti-Apolipoprotein A I antibody [EP1368Y]

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Primary Antibodies

AB312318

Anti-Apolipoprotein B antibody [EPR27473-49]

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Western blot - Anti-Apolipoprotein B antibody [EPR27473-49] (AB312318)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HDL also known as high-density lipoprotein serves an important role in lipid transport. It acts mainly in reverse cholesterol transport a process where HDL picks up cholesterol from peripheral tissues and delivers it back to the liver for excretion. The mass of HDL particles can vary but typically range between 8 to 12 nm in diameter depending on their lipid and protein content. HDL is primarily expressed in the liver and intestines. The principal protein components of HDL include apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II) which are essential for HDL's structure and function.
Biological function summary

Our high-density lipoprotein participates in cholesterol efflux a critical step in cholesterol homeostasis preventing cellular cholesterol accumulation. HDL acts as part of a complex with several enzymes and transporter proteins such as lecithin-cholesterol acyltransferase (LCAT) and ATP-binding cassette transporters A1 and G1 (ABCA1 ABCG1). These interactions enhance the lipid transport capability enabling HDL to remodel and carry varied cargo including cholesterol and antioxidants. HDL's role in antioxidation and inflammation modulation has been studied extensively highlighting its importance beyond lipid transport.

Pathways

The involvement of high-density lipoprotein is important in the larger cholesterol metabolism and cardiovascular protection pathways. HDL participates in the reverse cholesterol transport pathway linked closely with lipid regulatory proteins like LCAT and cholesterol ester transfer protein (CETP). Furthermore HDL interacts with endothelial nitric oxide synthase (eNOS) emphasizing its role in cardiovascular health by maintaining endothelial function. This connection highlights its contribution to reducing the risk of atherosclerosis a pathway critical for vascular health.

Links between high-density lipoprotein and cardiovascular diseases like atherosclerosis and coronary artery disease are significant. Low levels of HDL are often associated with increased risk of these conditions. Beyond lipoprotein components proteins like CETP and scavenger receptor BI (SR-BI) have roles in these diseases affecting HDL metabolism and function. Research continues to explore the therapeutic potential of targeting HDL metabolism to mitigate these cardiovascular risks considering its intricate relationship with these proteins and pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
See full target information APOA1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Glia 70:1971-1991 PubMed35762396

2022

EphA4 regulates white matter remyelination after ischemic stroke through Ephexin-1/RhoA/ROCK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Cui Liu,Song Han,Jiayin Zheng,Hongyu Wang,Shujuan Li,Junfa Li
View all publications
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Product promise

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