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AB126252

Anti-Heat Shock Factor 2 Binding Protein antibody

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(6 Publications)

Rabbit Polyclonal Heat Shock Factor 2 Binding Protein antibody. Suitable for IHC-P, WB and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HSF2BP aa 1-250.

View Alternative Names

MEILB2, HSF2BP, Heat shock factor 2-binding protein

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Heat Shock Factor 2 Binding Protein antibody (AB126252)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Heat Shock Factor 2 Binding Protein antibody (AB126252)

ab126252, at 1/500, staining Heat Shock Factor 2 Binding Protein in Human U87 xenograft by immunohistochemistry [Paraffin Embedded Tissues (IHC-P).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Heat Shock Factor 2 Binding Protein antibody (AB126252)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Heat Shock Factor 2 Binding Protein antibody (AB126252)

ab126252, at 1/500, staining Heat Shock Factor 2 Binding Protein in Mouse Muscle by immunohistochemistry [Paraffin Embedded Tissues (IHC-P).

Western blot - Anti-Heat Shock Factor 2 Binding Protein antibody (AB126252)
  • WB

Unknown

Western blot - Anti-Heat Shock Factor 2 Binding Protein antibody (AB126252)

Gel concentration : 10%

All lanes:

Western blot - Anti-Heat Shock Factor 2 Binding Protein antibody (ab126252) at 1/1000 dilution

Lane 1:

NT2D1 whole cell lysate at 30 µg

Lane 2:

SK-N-SH whole cell lysate at 30 µg

Predicted band size: 38 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human HSF2BP aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

O75031

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Heat Shock Factor 2 Binding Protein (HSF2BP) takes part in the regulation of heat shock response by interacting with Heat Shock Factor 2 (HSF2). It has a molecular mass of approximately 39 kDa. Expression of HSF2BP occurs mainly in testes though smaller amounts might be found in other tissues. HSF2BP directly associates with HSF2 altering its activity under stress conditions and regulates the transcription of heat shock proteins that protect cells from stress-induced damage.
Biological function summary

HSF2BP modulates stress response mechanisms by influencing the availability of HSF2. It forms a complex with other proteins and regulates protein stability. This protein exerts control over the expression of genes involved in stress response and cellular protection. HSF2BP's activity equates to a regulatory checkpoint in the cellular stress response ensuring appropriate chaperone activity and protein folding.

Pathways

HSF2BP intersects with the molecular chaperone network and the protein quality control pathways in cells. It interacts with pathways involving HSF2 and Heat Shock Factor 1 (HSF1) both critical for maintaining cellular integrity under stress conditions. HSF2BP influences these pathways by regulating the dynamic assembly of the transcription complex impacting gene expression profiles during stress response events.

HSF2BP relates to reproductive and developmental health including infertility and neurodegenerative diseases. Aberrant expression or mutations in HSF2BP can disrupt the balance of cellular stress responses potentially contributing to disease states. Its interaction with HSF2 and HSF1 implicates it in disorders such as Alzheimer's where protein misfolding and stress response mechanisms are compromised. Understanding HSF2BP's role in these diseases could help to identify targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1 : RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed : 31242413). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis (PubMed : 9651507).
See full target information HSF2BP
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0331900 PubMed40939011

2025

C3AR1 may aggravate diabetic nephropathy by mediating oxidative stress via ITGB2 regulation in renal tubular epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Alex Abura,Shan Gao

Cell & bioscience 13:64 PubMed36964632

2023

Overexpression of HSF2 binding protein suppresses endoplasmic reticulum stress via regulating subcellular localization of CDC73 in hepatocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Zhang,Tao Wang,Jianbin Bi,Mengyun Ke,Yifan Ren,Mengzhou Wang,Zhaoqing Du,Wuming Liu,Liangshuo Hu,Xiaogang Zhang,Xuemin Liu,Bo Wang,Zheng Wu,Yi Lv,Lingzhong Meng,Rongqian Wu

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36:e22357 PubMed35593531

2022

MEIOK21 regulates oocyte quantity and quality via modulating meiotic recombination.

Applications

Unspecified application

Species

Unspecified reactive species

Yongliang Shang,Ju Huang,Weidong Li,Yanan Zhang,Xu Zhou,Qiqi Shao,Taicong Tan,Shen Yin,Liangran Zhang,Shunxin Wang

GeroScience 43:1921-1934 PubMed33846884

2021

Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice.

Applications

Unspecified application

Species

Unspecified reactive species

Rachana Trivedi,Bailey Knopf,Jitendra Kumar Tripathi,Shar Rakoczy,Gunjan D Manocha,Holly Brown-Borg,Donald A Jurivich

Nucleic acids research 48:6624-6639 PubMed32463460

2020

MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yongliang Shang,Tao Huang,Hongbin Liu,Yanlei Liu,Heng Liang,Xiaoxia Yu,Mengjing Li,Binyuan Zhai,Xiao Yang,Yudong Wei,Guoqiang Wang,Zijiang Chen,Shunxin Wang,Liangran Zhang

The journals of gerontology. Series A, Biological sciences and medical sciences 75:1846-1852 PubMed31612204

2019

Multifactorial Attenuation of the Murine Heat Shock Response With Age.

Applications

Unspecified application

Species

Unspecified reactive species

Donald A Jurivich,Gunjan D Manocha,Rachana Trivedi,Mary Lizakowski,Sharlene Rakoczy,Holly Brown-Borg
View all publications
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