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AB150968

Anti-HEATR1 antibody

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(2 Publications)

Rabbit Polyclonal HEATR1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HEATR1 aa 450-550.

View Alternative Names

BAP28, UTP10, HEATR1, HEAT repeat-containing protein 1, Protein BAP28, U3 small nucleolar RNA-associated protein 10 homolog

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-HEATR1 antibody (AB150968)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HEATR1 antibody (AB150968)

Immunofluorescent analysis of PFA/Triton X-100 fixed/permeabilized A431 cells labeling HEATR1 with ab150968 at 4 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human HEATR1 aa 450-550. The exact immunogen used to generate this antibody is proprietary information.

Q9H583

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HEATR1 also known as HEAT repeat-containing protein 1 is a cytoplasmic protein with a molecular mass of approximately 166 kDa. The protein features several HEAT repeats which are tandemly arranged alpha-helical motifs. HEATR1 expresses in various tissues with high levels detected in the testes and lower levels in brain and lungs. The protein plays a role in cellular processes like protein trafficking and folding contributing to ribosome biogenesis and maintenance of cell cycle progression.
Biological function summary

HEATR1 influences pathways involved in the assembly and maturation of the ribosomal machinery. It forms part of the ribosome assembly complex associating with other ribosome biogenesis factors to facilitate ribosome production. The involvement of HEATR1 in the assembly complex helps ensure the ribosomes are correctly formed and functional impacting protein synthesis efficiency.

Pathways

HEATR1 interacts with key regulators in the ribosome biogenesis pathway and is linked to cell cycle regulation. It connects to proteins such as NOP14 and WDR25 within these pathways highlighting its importance in ribosome assembly and cellular division. The accurate functioning of these pathways is critical for cell growth and proliferation affecting overall cellular health and metabolism.

HEATR1 may be related to ribosomopathies and certain cancers where defects in ribosome biogenesis or aberrant protein synthesis play a role. The protein’s interactions with NOP14 suggest potential connections with disorders in ribosome production which may lead to proliferation issues observed in malignancies. Understanding the role of HEATR1 can offer insights into the molecular mechanisms behind these conditions aiding in the development of new therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed : 38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed : 17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797). Involved in neuronal-lineage cell proliferation (PubMed : 38225354).
See full target information HEATR1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 10:530933 PubMed33505901

2021

E2F1 Induces KIF26A Transcription and Promotes Cell Cycle Progression CDK-RB-E2Fs Feedback Loop in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Xu,Lei Liu,Ranran Ma,Yawen Wang,Xu Chen,Haiting Liu,Youxin Ji,Tiantian Liu,Peng Gao

Acta biochimica et biophysica Sinica 52:1030-1039 PubMed32634230

2020

HEATR1 promotes proliferation in gastric cancer in vitro and in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Zhao,Yiping Zhu,Qingsheng Fu,Yimei Zhu,Guohai Zhao
View all publications
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