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AB121343

Anti-HEG1 antibody

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Rabbit Polyclonal HEG1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human HEG1 aa 100-250.

View Alternative Names

KIAA1237, HEG1, Protein HEG homolog 1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEG1 antibody (AB121343)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEG1 antibody (AB121343)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon tissue labelling HEG1 with ab121343 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEG1 antibody (AB121343)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEG1 antibody (AB121343)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling HEG1 with ab121343 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEG1 antibody (AB121343)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEG1 antibody (AB121343)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling HEG1 with ab121343 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEG1 antibody (AB121343)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEG1 antibody (AB121343)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling HEG1 with ab121343 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human HEG1 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q9ULI3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HEG1 also known as Heart of Glass (HEG) is a protein with a molecular mass of approximately 160 kDa. This protein is found mainly in endothelial cells and is known for playing mechanical and structural roles within these cells. HEG1 is expressed in various tissues but it is highly prominent in the cardiovascular system including the heart and blood vessels. The protein contains several conserved domains that hint at its significant structural roles in maintaining cell integrity.
Biological function summary

HEG1 assists in the connection between endothelial cells contributing to proper cardiovascular functions. It is a part of the HEG1-Junctional Adhesion Molecule-Cytoplasmic domain (JAM-C) complex which plays a role in maintaining endothelial junction stability. This function is pivotal for blood vessel formation and the overall regulation of vascular permeability. The interactions within this complex indicate the importance of HEG1 in cell adhesion and vascular development.

Pathways

HEG1 plays a role in the regulation of the Hippo signaling pathway and the cardiac progenitor cell differentiation pathway. The Hippo pathway which includes proteins like MST1/2 and LATS1/2 is important for regulating cell proliferation and apoptosis. HEG1 interacts with these pathway components providing insights into its involvement in cardiovascular morphogenesis and growth signaling networks. Such interactions highlight the pathway's role in cellular homeostasis and heart structure development.

HEG1 alterations relate to cardiovascular diseases and certain forms of cancer. In cardiovascular diseases HEG1 dysfunction can lead to compromised endothelial integrity contributing to conditions such as vascular malformations or aneurysms. In cancer interactions with proteins like vascular endothelial growth factor receptor 2 (VEGFR2) influence tumor angiogenesis and metastasis. Understanding these connections helps in designing therapeutic strategies targeting both vascular health and cancer.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions.
See full target information HEG1
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Product promise

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