AB20459

Anti-Helicobacter pylori antibody

Name: Anti-Helicobacter pylori antibody (ab20459) | Abcam
Brand: Abcam Limited
SKU: AB20459
Price: 420 USD
Availability: InStock

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(13 Publications)

Rabbit Polyclonal Helicobacter pylori antibody. Suitable for ELISA, IHC-P, ICC/IF and reacts with Helicobacter pylori samples. Cited in 13 publications. Immunogen corresponding to Cell preparation containing Helicobacter pylori protein.

View Alternative Names

H. pylori

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Helicobacter pylori

Applications

ELISA, IHC-P, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Whole cell lysate. Has not been absorbed and may react with related microorganisms.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Helicobacter pylori": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/5000", "ELISA-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/1000", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

>95% pure

Storage buffer

Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Helicobacter pylori often called H. pylori is a gram-negative spiral-shaped bacterium with a mass of about 3.39 megadaltons. This organism colonizes the human gastric epithelium where it survives in the acidic environment of the stomach. The bacterium expresses urease which breaks down urea to ammonia and carbon dioxide helping neutralize gastric acid. It attaches to the gastric mucosa using flagella for motility and adheres to host cells via adhesins. Researchers utilize specific staining methods such as the Helicobacter pylori stain and tools like anti-Helicobacter antibodies to detect and study this pathogen.

Biological function summary

Helicobacter pylori plays a significant role in gastric health by disrupting mucosal integrity. It engages in the secretion of virulence factors like CagA and VacA leading to changes in cellular signaling and inflammation. H. pylori does not operate as part of a large complex but its interactions with the gastric mucosa have substantial effects. Detection and diagnosis often employ tools like H. pylori IHC and H. pylori antibody kits which target the bacterium's proteins to confirm infection presence.

Pathways

H. pylori infection activates signaling routes including the NF-κB pathway and the MAPK pathway in gastric epithelial cells. These pathways contribute to inflammatory responses and immune cell activation leading to mucosal damage. Within these pathways proteins like tumor necrosis factor-alpha (TNF-α) and interleukin-8 (IL-8) play roles in mediating inflammation initiated by the bacterial colonization of the gastric lining.

Chronic H. pylori infection has strong associations with gastric ulcers and gastric cancer. The bacterium promotes persistent inflammation and cellular damage that can progress to malignancy. H. pylori-related disorders are linked with proteins such as CagA a known oncogenic factor that interferes with host cell signaling and promotes carcinogenesis. Detection and specific targeting by Helicobacter pylori antibodies play important roles in managing and studying these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Helicobacter pylori

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Publications (13)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:625 PubMed40825934

2025

Unraveling the Role of METTL3 in Helicobacter pylori-induced gastritis via m6A-CXCL1/NF-κB modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Qiutong Lu,Zhaopeng Wang,Shuixian Cao,Huan Wang,Nianshuang Li,Yi Hu,Wuhui Ding,Wei Zuo,Junbo Hong

Helicobacter 29:e13069 PubMed38516860

2024

Helicobacter pylori enhances HLA-C expression in the human gastric adenocarcinoma cells AGS and can protect them from the cytotoxicity of natural killer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Etikala Apoorva,Rini Jacob,Desirazu N Rao,Santosh Kumar

Frontiers in microbiology 13:962354 PubMed36147839

2022

Revealing the novel effect of Jinghua Weikang capsule against the antibiotic resistance of .

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofen Jia,Qiuyue Huang,Miaomiao Lin,Yingming Chu,Zongming Shi,Xuezhi Zhang,Hui Ye

Journal of biomedical science 28:72 PubMed34706729

2021

Enhanced enzymatic production of cholesteryl 6'-acylglucoside impairs lysosomal degradation for the intracellular survival of Helicobacter pylori.

Applications

Unspecified application

Species

Unspecified reactive species

Sasikala Muthusamy,Hau-Ming Jan,Ming-Yen Hsieh,Soumik Mondal,Wen-Chun Liu,Yi-An Ko,Wei-Yuan Yang,Kwok-Kong Tony Mong,Guang-Chao Chen,Chun-Hung Lin

Frontiers in microbiology 12:674560 PubMed34149664

2021

Unraveling the Novel Effect of Patchouli Alcohol Against the Antibiotic Resistance of .

Applications

Unspecified application

Species

Unspecified reactive species

Yuanzun Zhong,Liyao Tang,Qiuhua Deng,Li Jing,Jiao Zhang,Yao Zhang,Feng Yu,Yijun Ou,Shaoju Guo,Bin Huang,Hongying Cao,Ping Huang,Yifei Xu

Frontiers in pharmacology 12:666903 PubMed33995095

2021

Clinical Strains of With Strong Cell Invasiveness and the Protective Effect of Patchouli Alcohol by Improving miR-30b/C Mediated Xenophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Yifei Xu,Qiuhua Deng,Yuanzun Zhong,Li Jing,Haiwen Li,Jingwei Li,Huimin Yu,Huafeng Pan,Shaoju Guo,Hongying Cao,Ping Huang,Bin Huang

Frontiers in cellular and infection microbiology 10:566730 PubMed33194806

2020

Vitamin D3 Inhibits Infection by Activating the VitD3/VDR-CAMP Pathway in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Anni Zhou,Lei Li,Guiping Zhao,Li Min,Si Liu,Shengtao Zhu,Qingdong Guo,Chunjie Liu,Shutian Zhang,Peng Li

Molecular cell 80:210-226.e7 PubMed33002424

2020

A Repeat-Associated Small RNA Controls the Major Virulence Factors of Helicobacter pylori.

Applications

Unspecified application

Species

Unspecified reactive species

Sara K Eisenbart,Mona Alzheimer,Sandy R Pernitzsch,Sascha Dietrich,Stephanie Stahl,Cynthia M Sharma

Communications biology 3:120 PubMed32170208

2020

Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Hau-Ming Jan,Yi-Chi Chen,Tsai-Chen Yang,Lih-Lih Ong,Chia-Chen Chang,Sasikala Muthusamy,Andualem Bahiru Abera,Ming-Shiang Wu,Jacquelyn Gervay-Hague,Kwok-Kong Tony Mong,Chun-Hung Lin

Applied and environmental microbiology 84: PubMed29752266

2018

Helicobacter pylori Biofilm Formation Is Differentially Affected by Common Culture Conditions, and Proteins Play a Central Role in the Biofilm Matrix.

Applications

Unspecified application

Species

Unspecified reactive species

Ian H Windham,Stephanie L Servetas,Jeannette M Whitmire,Daniel Pletzer,Robert E W Hancock,D Scott Merrell

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Helicobacter pylori antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (13)

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