Rabbit Polyclonal HELZ2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human HELZ2.
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- Nature communications 14:2032023The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAhmad Luqman-Fatah,Yuzo Watanabe,Kazuko Uno,Fuyuki Ishikawa,John V Moran,Tomoichiro MiyoshiPubMed 36639706
- Emerging microbes & infections 9:2046-20602020Dysregulation of Ephrin receptor and PPAR signaling pathways in neural progenitor cells infected by Zika virus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSathya N Thulasi Raman,Elyse Latreille,Jun Gao,Wanyue Zhang,Jianguo Wu,Marsha S Russell,Lisa Walrond,Terry Cyr,Jessie R Lavoie,David Safronetz,Jingxin Cao,Simon Sauve,Aaron Farnsworth,Wangxue Chen,Pei-Yong Shi,Youchun Wang,Lisheng Wang,Michael Rosu-Myles,Xuguang LiPubMed 32873194
- Frontiers in microbiology 8:2402017HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDahlene N Fusco,Henry Pratt,Stephen Kandilas,Scarlett Se Yun Cheon,Wenyu Lin,D Alex Cronkite,Megha Basavappa,Kate L Jeffrey,Anthony Anselmo,Ruslan Sadreyev,Clarence Yapp,Xu Shi,John F O'Sullivan,Robert E Gerszten,Takuya Tomaru,Satoshi Yoshino,Tetsurou Satoh,Raymond T ChungPubMed 28265266
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human HELZ2. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BYK8
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
Target data
Function
Can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities (PubMed:37602378). Shows a strong preference for pyrimidine over purine residues for its nuclease activity (PubMed:37602378). Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (PubMed:16239304, PubMed:23525231).
Alternative names
KIAA1769, PRIC285, HELZ2, 3'-5' exoribonuclease HELZ2, ATP-dependent RNA helicase PRIC285, Helicase with zinc finger domain 2, PPAR-alpha-interacting complex protein 285, PPAR-gamma DNA-binding domain-interacting protein 1, Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein, PDIP1, PPAR-gamma DBD-interacting protein 1
Recommended products
Rabbit Polyclonal HELZ2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human HELZ2.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human HELZ2. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BYK8
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab129781 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
HELZ2 also known as Helicase Like Transcription Factor 2 is a protein characterized by its capacity to bind DNA and RNA. It possesses a DEAD box domain which makes it part of the DExH/D box helicases. HELZ2 has a molecular mass of about 247 kDa. This protein is widely expressed in various tissues especially abundant in the liver and brain. Additional research highlights its presence in the adipose tissue indicating its potential role in metabolic processes.
- Biological function summary
HELZ2 functions in gene expression regulation by interacting with nuclear receptors and transcription factors. It acts within a protein complex influencing transcriptional regulation through chromatin remodeling. By modulating key transcriptional activities HELZ2 affects numerous genetic pathways and signal transductions contributing to fundamental cellular functions including development and differentiation. Knockout studies of HELZ2 dbd or domain-binding disruption suggest significant involvement in cellular homeostasis.
- Pathways
This protein plays significant roles in lipid metabolism and the insulin signaling pathway. HELZ2 has connections to related proteins such as PPAR and SREBPs involved in regulating lipid homeostasis and metabolic balance. Through these pathways HELZ2 navigates the intricate regulatory network that maintains metabolic equilibrium exhibiting a profound influence on cellular metabolic processes.
- Associated diseases and disorders
HELZ2 is linked to obesity and type 2 diabetes due to its role in metabolic regulation. By interacting with PPAR and other metabolic regulators HELZ2 has implications in adipogenesis and energy homeostasis which are critical in the pathogenesis of these metabolic disorders. Understanding its function may offer insights into potential therapeutic targets for these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-HELZ2 antibody (ab129781)
All lanes: Western blot - Anti-HELZ2 antibody (ab129781) at 1/500 dilution
Lane 1: Extracts from Jurkat cells
Lane 2: Extracts from Jurkat cells with immunizing peptide
Predicted band size: 295 kDa
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