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AB239591

Anti-Hemojuvelin antibody [C1]

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(1 Publication)

Mouse Monoclonal Hemojuvelin antibody. Suitable for WB, IHC-P and reacts with Pig, Recombinant full length protein - Human, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HJV aa 200 to C-terminus.

View Alternative Names

HFE2, RGMC, HJV, Hemojuvelin, Hemochromatosis type 2 protein, Hemojuvelin BMP coreceptor, RGM domain family member C

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C1] (AB239591)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C1] (AB239591)

Paraffin-embedded human liver tissue stained for Hemojuvelin using ab239591 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-Hemojuvelin antibody [C1] (AB239591)
  • WB

Supplier Data

Western blot - Anti-Hemojuvelin antibody [C1] (AB239591)

All lanes:

Western blot - Anti-Hemojuvelin antibody [C1] (ab239591) at 2 µg/mL

Lane 1:

Pig liver lysate

Lane 2:

Rat liver lysate

Secondary

All lanes:

HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

Predicted band size: 45 kDa

false

Western blot - Anti-Hemojuvelin antibody [C1] (AB239591)
  • WB

Supplier Data

Western blot - Anti-Hemojuvelin antibody [C1] (AB239591)

All lanes:

Western blot - Anti-Hemojuvelin antibody [C1] (ab239591) at 5 µg/mL

All lanes:

Recombinant human Hemojuvelin protein

Predicted band size: 45 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C1

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Rat, Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human HJV aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6ZVN8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Hemojuvelin also known as HJV or RGMc is a glycosylphosphatidylinositol-anchored protein that plays a significant role in iron homeostasis. It has a molecular mass of about 42 kDa. Expression of hemojuvelin is mainly observed in the liver heart and skeletal muscles. This protein is essential for maintaining systemic iron levels and regulates how much iron is absorbed and stored in the body.
Biological function summary

Hemojuvelin interacts with other proteins to modulate iron metabolism. It acts as a coreceptor for bone morphogenetic proteins (BMPs) enhancing BMP signaling which is critical in regulating the peptide hormone hepcidin. Hemojuvelin itself is not part of a larger complex but it works closely with BMPs to control hepcidin expression. Hepcidin is the key hormone that dictates iron absorption and its release from macrophages maintaining iron balance.

Pathways

Hemojuvelin functions primarily within the BMP signaling and hepcidin regulatory pathways. The interaction with BMP6 is particularly critical. The BMP6-hemojuvelin complex boosts the SMAD signaling cascade resulting in increased hepcidin expression. This cascade impacts iron levels in the body by limiting intestinal iron absorption and controlling iron recycling by macrophages.

Hemojuvelin mutations can lead to juvenile hemochromatosis a condition characterized by excessive iron buildup in the body. This protein's dysfunction can severely affect iron homeostasis leading to detrimental health outcomes. Moreover its connection to the regulation of hepcidin links hemojuvelin to conditions like anemia of chronic disease where hepcidin expression is aberrantly increased or decreased. Understanding the interaction of hemojuvelin and hepcidin provides insights into the mechanisms behind these iron-related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed : 18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed : 18976966).
See full target information HJV
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:542 PubMed40691131

2025

HIF-1α alleviates ferroptosis in ulcerative colitis by regulation of GPX4.

Applications

Unspecified application

Species

Unspecified reactive species

Weitao Hu,Yanliang Cai,Daxing Cai,Zongchi Chen,Siying Huang,Su Zhang,Huie Zhuang,Taiyong Fang,Xiaoqing Chen
View all publications
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Product promise

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