AB48135

Anti-Hemopexin antibody

Name: Anti-Hemopexin antibody (ab48135) | Abcam
Brand: Abcam Limited
SKU: AB48135
Price: 535 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal Hemopexin antibody. Suitable for sELISA and reacts with Purified native protein - Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human Hemopexin.

View Alternative Names

Hemopexin, Beta-1B-glycoprotein, HPX

1 Images

Sandwich ELISA - Anti-Hemopexin antibody (AB48135)

sELISA

Unknown

Sandwich ELISA - Anti-Hemopexin antibody (AB48135)

Standard Curve for Hemopexin (Analyte : Hemopexin protein (ab98988)); dilution range 1pg/ml to 1μg/ml using Capture Antibody Mouse monoclonal [32] to Hemopexin (ab27711) at 5μg/ml and Detector Antibody Rabbit polyclonal to Hemopexin (ab48135) at 0.5μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

sELISA

applications

Immunogen

Native Full Length Protein corresponding to Human Hemopexin.

P02790

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "predicted", "sELISA-species-dilution-info": "", "sELISA-species-notes": "" }, "Purified native protein - Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>For sandwich ELISA, use this antibody as Detection at 0.5 µg/ml with Mouse monoclonal [32] to Hemopexin (<a href='/en-us/products/primary-antibodies/hemopexin-antibody-32-ab27711'>ab27711</a>) as Capture.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Hemopexin also known as HPX is a glycoprotein that transports heme in the blood. It has a molecular weight of approximately 57 kDa and is primarily expressed in the liver. Hemopexin binds to free heme with high affinity which prevents oxidative damage and conserves iron. It transports the heme to hepatocytes for breakdown and recycling protecting cells from iron-mediated toxicity and oxidative stress.

Biological function summary

The hemopexin function relates to protecting tissues from the harmful effects of free heme. Hemopexin does not work as part of a complex in this process but mainly acts independently. Its high binding affinity plays an important role in maintaining heme homeostasis in the plasma and tissues. By controlling heme levels hemopexin supports overall cellular health and function.

Pathways

The hemopexin molecular weight allows it to fit effectively within the heme metabolism and iron recycling pathways. This protein plays a significant role by delivering heme to the liver and facilitating its degradation by heme oxygenase. Hemopexin interacts closely with heme oxygenase and albumin two proteins important for the management of heme and iron levels in the body.

Several hemopexin functions contribute to the understanding of conditions such as hemolytic anemia and acute liver injury. In hemolytic anemia hemopexin helps mitigate the effects of increased heme levels due to excessive red blood cell breakdown. In the context of liver injury the protein assists in the detoxification process and supports hepatic function. Hemopexin-related proteins such as heme oxygenase link these diseases to hemopexin by their roles in managing oxidative stress and heme catabolism.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

See full target information Hemopexin

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 47:6130-6144 PubMed31037292

2019

Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Tongxing Song,Yang Yang,Hongkui Wei,Xiaowei Xie,Jinxin Lu,Qianhui Zeng,Jie Peng,Yuanfei Zhou,Siwen Jiang,Jian Peng

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Hemopexin antibody

Sandwich ELISA - Anti-Hemopexin antibody (AB48135)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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