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AB20269

Anti-Hepatitis A Virus antibody

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(1 Publication)

Goat Polyclonal Hepatitis A Virus antibody. Suitable for ELISA and reacts with Hepatitis A virus samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Hepatitis A Virus protein.

View Alternative Names

HAV

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Hepatitis A virus

Applications

ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

All viral antigens. Negative cross reactivity against MRC5 cells.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis A virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/1000", "ELISA-species-notes": "<p>This product may be used in place of neat antiserum in almost any appropriate antibody-based technique.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Sodium sulfate precipitation and ion exchange chromatography.
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis A Virus (HAV) is a small non-enveloped virus belonging to the Picornaviridae family. It possesses a single-stranded RNA genome that measures about 7.5 kilobases in length. The capsid of HAV with a mass around 27 kDa consists of proteins VP1 VP2 and VP3 which form a protective shell that facilitates the virus's stability and transmission. This virus is primarily found in the liver where it causes infection although it can also circulate in the bloodstream and be excreted in the feces.
Biological function summary

HAV plays a significant role in human health by causing liver inflammation. It does not form complexes with other proteins but its replication predominantly occurs in hepatocytes. Although HAV is not directly involved in forming complexes it effectively interacts with host cell machinery to produce viral proteins and new viral particles. These interactions ensure the virus thrives in a new environment by altering the cell's normal functions to favor its replication.

Pathways

HAV significantly influences immune response and inflammation pathways. The virus triggers these pathways to counter the body's antiviral defenses leading to liver inflammation and damage. During the infection HAV interacts with host proteins such as those regulating the interferon response potentially altering their normal biological roles. These interactions can modulate the signaling further complicating the immune response and enhancing viral replication.

HAV is most associated with acute hepatitis a liver disease characterized by jaundice fatigue and fever. The immune response exacerbates liver damage as the body attempts to clear the virus. Unlike some other hepatotropic viruses HAV does not cause chronic liver disease. The interaction of HAV with proteins involved in the inflammatory response such as cytokines exacerbates symptoms and impacts disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Hepatitis A Virus
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 11:e0162384 PubMed27598782

2016

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjia Fan,Shahab Zareyan,Wenchen Zhao,Yoko Shimizu,Tom A Pfeifer,Jun-Hyung Tak,Murray B Isman,Bernard Van den Hoven,Mark E Duggan,Michael W Wood,Cheryl L Wellington,Iva Kulic
View all publications
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