Goat Polyclonal Hepatitis A Virus antibody. Suitable for ELISA and reacts with Hepatitis A virus samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Hepatitis A Virus protein.
pH: 7.2
Preservative: 0.1% Sodium azide
Constituents: 0.0268% PBS
| ELISA | |
|---|---|
| Hepatitis A virus | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis A virus | Dilution info Use at an assay dependent concentration. | Notes - |
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HAV
Goat Polyclonal Hepatitis A Virus antibody. Suitable for ELISA and reacts with Hepatitis A virus samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Hepatitis A Virus protein.
pH: 7.2
Preservative: 0.1% Sodium azide
Constituents: 0.0268% PBS
This antibody reacts with Hepatitis A virions in viral and infected tissue samples.
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The Hepatitis A Virus (HAV) is a small non-enveloped virus belonging to the Picornaviridae family. It possesses a single-stranded RNA genome that measures about 7.5 kilobases in length. The capsid of HAV with a mass around 27 kDa consists of proteins VP1 VP2 and VP3 which form a protective shell that facilitates the virus's stability and transmission. This virus is primarily found in the liver where it causes infection although it can also circulate in the bloodstream and be excreted in the feces.
HAV plays a significant role in human health by causing liver inflammation. It does not form complexes with other proteins but its replication predominantly occurs in hepatocytes. Although HAV is not directly involved in forming complexes it effectively interacts with host cell machinery to produce viral proteins and new viral particles. These interactions ensure the virus thrives in a new environment by altering the cell's normal functions to favor its replication.
HAV significantly influences immune response and inflammation pathways. The virus triggers these pathways to counter the body's antiviral defenses leading to liver inflammation and damage. During the infection HAV interacts with host proteins such as those regulating the interferon response potentially altering their normal biological roles. These interactions can modulate the signaling further complicating the immune response and enhancing viral replication.
HAV is most associated with acute hepatitis a liver disease characterized by jaundice fatigue and fever. The immune response exacerbates liver damage as the body attempts to clear the virus. Unlike some other hepatotropic viruses HAV does not cause chronic liver disease. The interaction of HAV with proteins involved in the inflammatory response such as cytokines exacerbates symptoms and impacts disease progression.
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We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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