Mouse Monoclonal Hepatitis B Surface Antigen (Adw) antibody. Carrier free. Suitable for ELISA, WB, ICC/IF, IM and reacts with Hepatitis B virus samples.
IgG1
Mouse
Constituents: PBS
Liquid
Monoclonal
| ELISA | WB | ICC/IF | IM | |
|---|---|---|---|---|
| Hepatitis B virus | Expected | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis B virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis B virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis B virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis B virus | Dilution info Use at an assay dependent concentration. | Notes - |
S gene subtype adw2, sAg, ssAg
Mouse Monoclonal Hepatitis B Surface Antigen (Adw) antibody. Carrier free. Suitable for ELISA, WB, ICC/IF, IM and reacts with Hepatitis B virus samples.
IgG1
Mouse
Constituents: PBS
Liquid
Monoclonal
Yes
B3228M
Affinity purification Protein A
HBsAg pre-S2 antigen (amino acids 132-137, sequence 'AGGSSS') (adw nomenclature). Reference start codon was Pre-S1. Epitope recognition confirmed by competing with peptides.
Purified from TCS.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
The Hepatitis B Surface Antigen (Adw) often called 'HBsAg Adw' or just 'Adw' serves as a marker for the hepatitis B virus (HBV) infection. It is a structural protein with an approximate mass of 24 kDa. It prominently expresses on the surface of HBV and infectious particles in the bloodstream of infected individuals. This antigen is key in serological diagnosis and monitoring of HBV providing an indicator of viral presence and replication status in the host.
The Hepatitis B Surface Antigen plays a central role in the life cycle of the virus. It participates in the formation of the viral envelope an essential step for virion assembly and release. Additionally it associates with other proteins as part of a nucleocapsid complex that encapsulates and protects the viral DNA within the host organism. This interaction facilitates immune evasion and allows persistent infection making HBsAg an important factor in chronic hepatitis B infection.
The surface antigen of HBV integrates itself into the viral replication and host immune response pathways. HBsAg impacts the host immune regulation by modulating pathways that normally detect and clear foreign antigens. It interferes with cytokine signaling pathways which include interactions with proteins like interferons that serve as antiviral agents. These protein interactions hamper the host's ability to mount an effective immune response fostering a suitable environment for viral persistence.
Hepatitis B Surface Antigen is intimately connected to hepatic diseases such as hepatitis B infection and hepatocellular carcinoma (HCC). Persistent expression of HBsAg in patients indicates chronic infection significantly increasing the risk of liver damage and cancer development. Liver fibrosis and cirrhosis are also linked to HBsAg often observed in tandem with proteins like core antigen HBcAg which exacerbates inflammation and cellular damage. This relationship underlines HBsAg's importance in the pathogenesis and progression of HBV-related liver diseases.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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