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AB252692

Anti-Hepatitis B Surface Antigen (Adw) antibody [B3228M]

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(2 Publications)

Mouse Monoclonal Hepatitis B Surface Antigen (Adw) antibody. Carrier free. Suitable for ELISA, WB, ICC/IF, IM and reacts with Hepatitis B virus samples. Cited in 2 publications.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

B3228M

Isotype

IgG1

Carrier free

Yes

Reacts with

Hepatitis B virus

Applications

ELISA, WB, ICC/IF, IM

applications

Specificity

HBsAg pre-S2 antigen (amino acids 132-137, sequence 'AGGSSS') (adw nomenclature). Reference start codon was Pre-S1. Epitope recognition confirmed by competing with peptides.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IM" : {"fullname" : "Immunomicroscopy", "shortname":"IM"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis B virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IM-species-checked": "guaranteed", "IM-species-dilution-info": "", "IM-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Purified from TCS.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis B Surface Antigen (Adw) often called 'HBsAg Adw' or just 'Adw' serves as a marker for the hepatitis B virus (HBV) infection. It is a structural protein with an approximate mass of 24 kDa. It prominently expresses on the surface of HBV and infectious particles in the bloodstream of infected individuals. This antigen is key in serological diagnosis and monitoring of HBV providing an indicator of viral presence and replication status in the host.
Biological function summary

The Hepatitis B Surface Antigen plays a central role in the life cycle of the virus. It participates in the formation of the viral envelope an essential step for virion assembly and release. Additionally it associates with other proteins as part of a nucleocapsid complex that encapsulates and protects the viral DNA within the host organism. This interaction facilitates immune evasion and allows persistent infection making HBsAg an important factor in chronic hepatitis B infection.

Pathways

The surface antigen of HBV integrates itself into the viral replication and host immune response pathways. HBsAg impacts the host immune regulation by modulating pathways that normally detect and clear foreign antigens. It interferes with cytokine signaling pathways which include interactions with proteins like interferons that serve as antiviral agents. These protein interactions hamper the host's ability to mount an effective immune response fostering a suitable environment for viral persistence.

Hepatitis B Surface Antigen is intimately connected to hepatic diseases such as hepatitis B infection and hepatocellular carcinoma (HCC). Persistent expression of HBsAg in patients indicates chronic infection significantly increasing the risk of liver damage and cancer development. Liver fibrosis and cirrhosis are also linked to HBsAg often observed in tandem with proteins like core antigen HBcAg which exacerbates inflammation and cellular damage. This relationship underlines HBsAg's importance in the pathogenesis and progression of HBV-related liver diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Hepatitis B Surface Antigen (Adw)
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Current protocols 4:e1030 PubMed38923763

2024

Applications of Surface Plasmon Resonance (SPR) to the Study of Diverse Protein-Ligand Interactions.

Applications

Unspecified application

Species

Unspecified reactive species

Dana M Burris,Samuel W Gillespie,Emma Joy Campbell,S Nick Ice,Vikas Yadav,William D Picking,Christian L Lorson,Kamal Singh

mBio 13:e0370521 PubMed35229634

2022

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication and Decreases Viral Titers and Disease Progression in Syrian Hamsters.

Applications

Unspecified application

Species

Unspecified reactive species

Iart Luca Shytaj,Mohamed Fares,Lara Gallucci,Bojana Lucic,Mahmoud M Tolba,Liv Zimmermann,Julia M Adler,Na Xing,Judith Bushe,Achim D Gruber,Ina Ambiel,Ahmed Taha Ayoub,Mirko Cortese,Christopher J Neufeldt,Bettina Stolp,Mohamed Hossam Sobhy,Moustafa Fathy,Min Zhao,Vibor Laketa,Ricardo Sobhie Diaz,Richard E Sutton,Petr Chlanda,Steeve Boulant,Ralf Bartenschlager,Megan L Stanifer,Oliver T Fackler,Jakob Trimpert,Andrea Savarino,Marina Lusic
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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