AB8638

Anti-Hepatitis B Virus Core Antigen antibody [14E11]

Name: Anti-Hepatitis B Virus Core Antigen antibody [14E11] (ab8638) | Abcam
Brand: Abcam Limited
SKU: AB8638
Price: 590 USD
Availability: InStock

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(17 Publications)

Mouse Monoclonal Hepatitis B Virus Core Antigen antibody. Suitable for IP, ELISA, WB, IHC-FoFr, IHC-P, ICC/IF, IHC-Fr and reacts with Hepatitis B virus samples. Cited in 17 publications.

View Alternative Names

Capsid Protein, Core and e antigen, Core antigen, Core protein, HBVgp4, HBc, HBcAg, Hepatitis B Virus core antigen, Hepatitis B core antigen, p21.5, precore/core protein

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

14E11

Isotype

IgG2b

Light chain type

kappa

Carrier free

Reacts with

Hepatitis B virus

Applications

IHC-P, IHC-Fr, ELISA, WB, IP, ICC/IF, IHC-FoFr

applications

Epitope

135-141aa (PNAPILS)

Specificity

ab8638 was raised against serotype ayw but will work with all other genotypes.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis B virus": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCFoFr-species-checked": "guaranteed", "IHCFoFr-species-dilution-info": "1/100", "IHCFoFr-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "1/100", "IHCFr-species-notes": "" } } }

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Product details

This product is raised in the same, but denatured, HBcAg protein sequence as ab8637, hence have more robust activity in denaturing western blots/IF etc.

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Properties and storage information

Form

Liquid

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis B Virus Core Antigen also known as HBV core antigen or Hep B core is an important component of the hepatitis B virus (HBV). This antigen often referred to simply as 'core' forms the nucleocapsid of the virus. The HBV core antigen consists of a protein structure with a mass of approximately 21 kilodaltons. It is primarily expressed within the hepatocytes the liver cells where it plays a pivotal role in viral replication and assembly. The HBV core antigen is also referred to in studies as HBV protein or B core.

Biological function summary

The hepatitis B core antigen is integral for the assembly of the viral capsid which protects the viral genome during infection. It functions as part of a larger complex with other viral proteins including the pre-core and envelope proteins to facilitate viral lifecycle processes. This antigen allows for the encapsidation of viral RNA and serves as a scaffold for reverse transcription of the viral genome ensuring replication fidelity and successful infection spread.

Pathways

The hepatitis B core antigen is essential in the viral replication pathway and the HBV lifecycle pathway. It interacts closely with HBV polymerase during the packaging of viral genome into the capsid. These interactions are important for the transformation of RNA into DNA a critical step in viral maturation. The antigen is related to the HBx protein through these pathways; the HBx protein modulates viral replication and can influence the pathogenesis of the virus.

The hepatitis B core antigen is strongly linked to chronic hepatitis B infection and liver diseases such as cirrhosis and hepatocellular carcinoma. The persistence of the core antigen in infected hepatocytes signifies ongoing viral replication which can lead to liver inflammation and damage. The interaction of the core antigen with immune system components such as anti-HBc antibodies assists in the diagnosis and monitoring of disease progression. It connects to the envelope proteins during the disease process which are important in immune system evasion and chronic infection establishment.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Hepatitis B Virus Core Antigen

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Publications (17)

Recent publications for all applications. Explore the full list and refine your search

MedComm 6:e70365 PubMed40919132

2025

HBV Precore G1896A Mutation Promotes Malignancy of Hepatocellular Carcinoma by Activating Endoplasmic Reticulum Stress to Enhance Aerobic Glycolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Baoxin Zhao,Hongxiu Qiao,Zhiyun Gao,Yan Zhao,Weijie Wang,Yan Cui,Fangxu Li,Yuping Wang,Zhanjun Guo,Xia Chuai,Sandra Chiu

Viruses 15: PubMed38140543

2023

Replication and Expression of the Consensus Genome of Hepatitis B Virus Genotype C from the Chinese Population.

Applications

Unspecified application

Species

Unspecified reactive species

Fenfang Liao,Junmou Xie,Rongsong Du,Wenbo Gao,Lanyin Lan,Min Wang,Xia Rong,Yongshui Fu,Hao Wang

Virologica Sinica 38:680-689 PubMed37331658

2023

HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Baoxin Zhao,Hongxiu Qiao,Yan Zhao,Zhiyun Gao,Weijie Wang,Yan Cui,Jian Li,Zhanjun Guo,Xia Chuai,Sandra Chiu

Oncology letters 24:424 PubMed36284651

2022

DNA methylation at hepatitis B virus integrants and flanking host mitochondrially encoded cytochrome C oxidase III.

Applications

Unspecified application

Species

Unspecified reactive species

Ritsuko Oikawa,Yoshiyuki Watanabe,Hiroshi Yotsuyanagi,Hiroyuki Yamamoto,Fumio Itoh

BMC infectious diseases 22:431 PubMed35509029

2022

Signature of chronic hepatitis B virus infection in nails and hair.

Applications

Unspecified application

Species

Unspecified reactive species

Haruki Komatsu,Ayano Inui,Enkhtaivan Odmaa,Yoshinori Ito,Hiroki Hoshino,Shuichiro Umetsu,Tomoyuki Tsunoda,Tomoo Fujisawa

JHEP reports : innovation in hepatology 3:100330 PubMed34409278

2021

Evidence for long-term association of virion-delivered HBV core protein with cccDNA independently of viral protein production.

Applications

Unspecified application

Species

Unspecified reactive species

Julie Lucifora,Florentin Pastor,Émilie Charles,Caroline Pons,Héloïse Auclair,Floriane Fusil,Michel Rivoire,François-Loïc Cosset,David Durantel,Anna Salvetti

Vaccines 9: PubMed33669126

2021

-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles.

Applications

Unspecified application

Species

Unspecified reactive species

Noelle Colant,Beatrice Melinek,Stefanie Frank,William Rosenberg,Daniel G Bracewell

Molecular therapy. Nucleic acids 22:114-123 PubMed32916597

2020

ROS/NF-κB Signaling Pathway-Mediated Transcriptional Activation of TRIM37 Promotes HBV-Associated Hepatic Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Haina Xie,Dongyu Xie,Jingxian Zhang,Wenye Jin,Yue Li,Jun Yao,Zhiqiang Pan,Donghao Xie

Human vaccines & immunotherapeutics 16:756-778 PubMed31687879

2019

A dendritic cell receptor-targeted chimeric immunotherapeutic protein (C-HBV) for the treatment of chronic hepatitis B.

Applications

Unspecified application

Species

Unspecified reactive species

Allan Ma,Bruce Motyka,Klaus Gutfreund,Yuenian Eric Shi,Rajan George

Frontiers in microbiology 10:2382 PubMed31681236

2019

NF-κB-Dependent IFIT3 Induction by HBx Promotes Hepatitis B Virus Replication.

Applications

Unspecified application

Species

Unspecified reactive species

Fengchao Xu,Hongxiao Song,Beiying An,Qingfei Xiao,Genhong Cheng,Guangyun Tan

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Hepatitis B Virus Core Antigen antibody [14E11]

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Epitope

Specificity

Reactivity data

Product details

Properties and storage information

Form

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (17)

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Product promise