AB115992

Anti-Hepatitis B Virus Core Antigen antibody

Name: Anti-Hepatitis B Virus Core Antigen antibody (ab115992) | Abcam
Brand: Abcam Limited
SKU: AB115992
Price: 470 USD
Availability: InStock
Rating: 3 (1 reviews)

(1 Review)

(19 Publications)

Anti-Hepatitis B Virus Core Antigen antibody (ab115992) is a rabbit polyclonal antibody detecting Hepatitis B Virus Core Antigen in IHC-P, IHC-Fr. Suitable for Hepatitis B virus.

- Over 10 publications

View Alternative Names

Capsid Protein, Core and e antigen, Core antigen, Core protein, HBVgp4, HBc, HBcAg, Hepatitis B Virus core antigen, Hepatitis B core antigen, p21.5, precore/core protein

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Hepatitis B virus

Applications

IHC-P, IHC-Fr

applications

Specificity

Serotype specificity information is not available for this antibody

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis B virus": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }

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Product details

What is this antibody validated in?
Anti-Hepatitis B Virus Core Antigen antibody (ab115992) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Hepatitis B virus samples.

Trusted by the scientific community
Anti-Hepatitis B Virus Core Antigen (ab115992) was first used in a scientific publication in 2011 and has been cited over 10 times in peer-reviewed journals.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 1.17% Sodium chloride, 0.11998% Sodium dihydrogen phosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis B Virus Core Antigen also known as HBV core antigen or Hep B core is an important component of the hepatitis B virus (HBV). This antigen often referred to simply as 'core' forms the nucleocapsid of the virus. The HBV core antigen consists of a protein structure with a mass of approximately 21 kilodaltons. It is primarily expressed within the hepatocytes the liver cells where it plays a pivotal role in viral replication and assembly. The HBV core antigen is also referred to in studies as HBV protein or B core.

Biological function summary

The hepatitis B core antigen is integral for the assembly of the viral capsid which protects the viral genome during infection. It functions as part of a larger complex with other viral proteins including the pre-core and envelope proteins to facilitate viral lifecycle processes. This antigen allows for the encapsidation of viral RNA and serves as a scaffold for reverse transcription of the viral genome ensuring replication fidelity and successful infection spread.

Pathways

The hepatitis B core antigen is essential in the viral replication pathway and the HBV lifecycle pathway. It interacts closely with HBV polymerase during the packaging of viral genome into the capsid. These interactions are important for the transformation of RNA into DNA a critical step in viral maturation. The antigen is related to the HBx protein through these pathways; the HBx protein modulates viral replication and can influence the pathogenesis of the virus.

The hepatitis B core antigen is strongly linked to chronic hepatitis B infection and liver diseases such as cirrhosis and hepatocellular carcinoma. The persistence of the core antigen in infected hepatocytes signifies ongoing viral replication which can lead to liver inflammation and damage. The interaction of the core antigen with immune system components such as anti-HBc antibodies assists in the diagnosis and monitoring of disease progression. It connects to the envelope proteins during the disease process which are important in immune system evasion and chronic infection establishment.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Hepatitis B Virus Core Antigen

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Publications (19)

Recent publications for all applications. Explore the full list and refine your search

NPJ vaccines 10:138 PubMed40592944

2025

Modular assembly and immunological evaluation of a promising bioconjugate nanovaccine against Klebsiella pneumoniae O2 serotype.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Sun,Chao Pan,Huifang Xu,Bo Liu,Jingqin Ye,Kangfeng Wang,Yan Zhang,Ting Li,Li Zhu,Yating Wang,Hengliang Wang,Jun Wu

Vaccines 13: PubMed40432076

2025

Immunogenicity of an Intranasal Dual (Core and Surface)-Antigen Vaccine Against Hepatitis B Virus Enhanced by Carboxyl-Vinyl Polymer Excipients.

Applications

Unspecified application

Species

Unspecified reactive species

Md Haroon Or Rashid,Fumihiko Yasui,Takahiro Sanada,Risa Kono,Tomoko Honda,Bouchra Kitab,Lipi Akter,Masashi Utsunomiya,Risa Sato,Osamu Yoshida,Yoichi Hiasa,Yasunori Oda,Yasumasa Goh,Takashi Miyazaki,Michinori Kohara,Kyoko Tsukiyama-Kohara

Virus research 354:199550 PubMed39988206

2025

Adeno-associated virus 2 CRISPR/Cas9-mediated targeting of hepatitis B virus in tree shrews.

Applications

Unspecified application

Species

Unspecified reactive species

Md Haroon Or Rashid,Mohammad Enamul Hoque Kayesh,Md Abul Hashem,Tatsuro Hifumi,Shintaro Ogawa,Noriaki Miyoshi,Yasuhito Tanaka,Michinori Kohara,Kyoko Tsukiyama-Kohara

Journal of virology 98:e0150223 PubMed38315015

2024

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level is dependent on core protein translation.

Applications

Unspecified application

Species

Unspecified reactive species

Jan Martin Berke,Ying Tan,Sarah Sauviller,Dai-Tze Wu,Ke Zhang,Nádia Conceição-Neto,Alfonso Blázquez Moreno,Desheng Kong,George Kukolj,Chris Li,Ren Zhu,Isabel Nájera,Frederik Pauwels

Journal of virology 97:e0072223 PubMed37754761

2023

Novel non-HAP class A HBV capsid assembly modulators have distinct and profiles.

Applications

Unspecified application

Species

Unspecified reactive species

Hannah Vanrusselt,Dieudonné Buh Kum,Valerio Taverniti,Cheng Liu,Abel Acosta Sanchez,Nikky Corthout,Sebastian Munck,Thomas F Baumert,Leonid Beigelman,Lawrence M Blatt,Julian A Symons,Jerome Deval,Pierre Raboisson,Eloi R Verrier,Andreas Jekle,Sandrine Vendeville,Yannick Debing

Experimental and therapeutic medicine 25:167 PubMed36936705

2023

Exosomes from Ub‑HBcAg‑overexpressing dendritic cells induce T‑lymphocyte differentiation and enhance cytotoxic T‑lymphocyte activity.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhang Yang,Kanghao Liu,Wenwen Zhou,Shenglan Dai

Cellular and molecular gastroenterology and hepatology 15:533-558 PubMed36270602

2022

Hepatitis B Virus Utilizes a Retrograde Trafficking Route via the Trans-Golgi Network to Avoid Lysosomal Degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Ying-Yi Li,Kazuyuki Kuroki,Tetsuro Shimakami,Kazuhisa Murai,Kazunori Kawaguchi,Takayoshi Shirasaki,Kouki Nio,Saiho Sugimoto,Tomoki Nishikawa,Hikari Okada,Noriaki Orita,Hideo Takayama,Ying Wang,Phuong Doan Thi Bich,Astuya Ishida,Sadahiro Iwabuchi,Shinichi Hashimoto,Takeshi Shimaoka,Noriko Tabata,Miho Watanabe-Takahashi,Kiyotaka Nishikawa,Hiroshi Yanagawa,Motoharu Seiki,Kouji Matsushima,Taro Yamashita,Shuichi Kaneko,Masao Honda

Nature communications 13:2995 PubMed35637225

2022

Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Sreya Biswas,Lauren N Rust,Jochen M Wettengel,Sofiya Yusova,Miranda Fischer,Julien N Carson,Josie Johnson,Lei Wei,Trason Thode,Mohan R Kaadige,Sunil Sharma,Majd Agbaria,Benjamin N Bimber,Thomas Tu,Ulrike Protzer,Alexander Ploss,Jeremy V Smedley,Gershon Golomb,Jonah B Sacha,Benjamin J Burwitz

Bio-protocol 12:e4392 PubMed35800100

2022

Production of Recombinant Hepatitis B virus (HBV) and Detection of HBV in Infected Human Liver Organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Tanvir Hossain,Shahla Romal,Tokameh Mahmoudi

Infection and drug resistance 15:961-973 PubMed35299854

2022

Inhibition of Protease Activated Receptor 2 Attenuates HBx-Induced Inflammation and Mitochondria Oxidative Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Li,Yonggang Li,Shuhua Li,Hongwei Li,Ling Liu,Yao Xu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Hepatitis B Virus Core Antigen antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (19)

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