Mouse Monoclonal HBSAG antibody. Suitable for IP, ELISA, IHC-FoFr, ICC/IF, IHC-Fr and reacts with Hepatitis B virus samples. Cited in 4 publications.
| IP | ELISA | IHC-FoFr | ICC/IF | IHC-Fr | |
|---|---|---|---|---|---|
| Hepatitis B virus | Expected | Expected | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis B virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis B virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis B virus | Dilution info 1/100 | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis B virus | Dilution info 1/100 | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis B virus | Dilution info 1/100 | Notes - |
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The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein. The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
Large envelope protein, L glycoprotein, L-HBsAg, Large S protein, Large surface protein, Major surface antigen, LHB, S
Mouse Monoclonal HBSAG antibody. Suitable for IP, ELISA, IHC-FoFr, ICC/IF, IHC-Fr and reacts with Hepatitis B virus samples. Cited in 4 publications.
This antibody reacts with HBV Small Surface Antigen
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The Hepatitis B Virus Surface Antigen commonly known as HBsAg is an important structural protein of the Hepatitis B Virus (HBV). This antigen is also referred to as Hep B surf Ab. Designed with a mass of approximately 24 kDa HBsAg is expressed extensively in the liver tissues of individuals infected with Hepatitis B. It represents the major component of the virus's envelope and plays a role in the formation of subviral particles. Several commercial antibodies such as Hepatitis antibodies and HBV antibodies target HBsAg for analytical and diagnostic purposes in laboratories.
The Hepatitis B Virus Surface Antigen interacts with the host's immune system and assists in viral replication. HBsAg is not part of a larger protein complex. Rather it circulates as free particles known as 3e-7 and 3e-7 Hepatitis B antigens which are abundant in the blood serum during active infection. These particles act as decoys distracting the host's immune defense and facilitating the persistence of the infection. The production and clearance of HBsAg serve as important indicators of HBV infection status and disease progression.
Hepatitis B Virus Surface Antigen plays an integral role in the HBV life cycle particularly within the viral entry and replication pathways. It shares a functional relationship with the HB5 protein which is important for viral particle assembly and release. The interactions between HBsAg and host proteins influence viral propagation and subsequently the overall pathway of HBV infection within hepatocytes. Understanding these interactions can aid in the development of therapeutic interventions to disrupt the viral lifecycle.
Hepatitis B Virus Surface Antigen is directly associated with chronic Hepatitis B infection and hepatocellular carcinoma. Chronic Hepatitis B characterized by the prolonged presence of HBsAg can advance to liver cirrhosis and cancer if untreated. The antigen's persistence is often monitored alongside liver enzymes and other markers such as Hepatitis B antibodies (Hep B antibodies) to assess disease progression and treatment efficacy. Effective management of HBsAg levels helps mitigate the risk and severity of these severe liver diseases.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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