Mouse Monoclonal POLG antibody. Suitable for ELISA, IHC-P and reacts with Hepatitis C virus samples.
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: PBS
| ELISA | IHC-P | |
|---|---|---|
| Hepatitis C virus | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis C virus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Hepatitis C virus | Dilution info Use at an assay dependent concentration. | Notes - |
HCV, HCV antigen, Hepatitis C Virus
Mouse Monoclonal POLG antibody. Suitable for ELISA, IHC-P and reacts with Hepatitis C virus samples.
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: PBS
Hepatitis C Virus antigen NS4B.
The Hepatitis C Virus (HCV) antigen consists of several proteins important to the viral life cycle including core envelope and nonstructural proteins. The core protein often referred to as HCV core or C protein has a mass of about 21 kDa. It forms an important structural component of the virus and is expressed primarily in liver cells where the virus replicates. This antigen facilitates viral assembly aids in RNA packaging and plays a role in forming the virus particle.
The Hepatitis C Virus antigen participates in the replication and infection processes of the virus. It also contributes to the host's immune evasion. The HCV antigen part of a complex involving host proteins disrupts cellular processes to enhance viral survival. The interaction between the core protein and cellular machinery can alter immune regulation and apoptosis creating an environment conducive to persistent infection.
Hepatitis C Virus antigen forms part of the viral replication and protein translation pathways within the host cell. It interacts with the mTOR and MAPK signaling pathways. Within these pathways the core protein engages with cellular proteins such as ras and PI3K modulating cell growth and survival in favor of the virus.
Hepatitis C Virus antigen is integral to hepatitis C infection leading to liver diseases like cirrhosis and hepatocellular carcinoma. The interaction of the antigen with toll-like receptors (TLR) and cytokines exacerbates inflammatory responses contributing to liver tissue damage. In hepatocellular carcinoma altered expression and interaction of proteins like TLR and core antigen promote oncogenic transformation.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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