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AB13832

Anti-Hepatitis C Virus antigen antibody [H25]

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(1 Publication)

Mouse Monoclonal POLG antibody. Suitable for ELISA, IHC-P and reacts with Hepatitis C virus samples. Cited in 1 publication.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

H25

Isotype

IgG1

Carrier free

No

Reacts with

Hepatitis C virus

Applications

IHC-P, ELISA

applications

Specificity

Hepatitis C Virus antigen NS4B.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis C virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis C Virus (HCV) antigen consists of several proteins important to the viral life cycle including core envelope and nonstructural proteins. The core protein often referred to as HCV core or C protein has a mass of about 21 kDa. It forms an important structural component of the virus and is expressed primarily in liver cells where the virus replicates. This antigen facilitates viral assembly aids in RNA packaging and plays a role in forming the virus particle.
Biological function summary

The Hepatitis C Virus antigen participates in the replication and infection processes of the virus. It also contributes to the host's immune evasion. The HCV antigen part of a complex involving host proteins disrupts cellular processes to enhance viral survival. The interaction between the core protein and cellular machinery can alter immune regulation and apoptosis creating an environment conducive to persistent infection.

Pathways

Hepatitis C Virus antigen forms part of the viral replication and protein translation pathways within the host cell. It interacts with the mTOR and MAPK signaling pathways. Within these pathways the core protein engages with cellular proteins such as ras and PI3K modulating cell growth and survival in favor of the virus.

Hepatitis C Virus antigen is integral to hepatitis C infection leading to liver diseases like cirrhosis and hepatocellular carcinoma. The interaction of the antigen with toll-like receptors (TLR) and cytokines exacerbates inflammatory responses contributing to liver tissue damage. In hepatocellular carcinoma altered expression and interaction of proteins like TLR and core antigen promote oncogenic transformation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Hepatitis C Virus antigen
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 20:e1012782 PubMed39693295

2024

Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1 and blocking the binding of HMGB1 to the viral genome.

Applications

Unspecified application

Species

Unspecified reactive species

Penghui Hu,Huiyi Li,Zemin Ji,Weijia Jing,Zihan Li,Sujun Yu,Xiao Shan,Yan Cui,Baochen Wang,Hongyuan Dong,Yanzhao Zhou,Zhe Wang,Hui Xiong,Xiaomei Zhang,Hui-Chieh Li,Jinrong Wang,Jiuzhou Tang,Ting Wang,Keliang Xie,Yuping Liu,Haizhen Zhu,Qiujing Yu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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