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AB2740

Anti-Hepatitis C Virus Core 1b antibody [C7-50]

4

(3 Reviews)

|

(99 Publications)

Mouse Monoclonal POLG antibody. Suitable for IP, Flow Cyt, ELISA, WB and reacts with Hepatitis C virus samples. Cited in 99 publications.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C7-50

Isotype

IgG1

Carrier free

No

Reacts with

Hepatitis C virus

Applications

Flow Cyt, ELISA, WB, IP

applications

Epitope

This antibody recognizes an epitope between amino acid residues 21-40 of HCV core protein. This sequence is conserved among different HCV strains.

Specificity

Detects hepatitis C virus (HCV) core protein from transfected human and primate cell lines.

Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis C Virus Core 1b also recognized as HCV Core Protein or sometimes abbreviated as HCV Core is an important structural protein of the Hepatitis C Virus weighing approximately 21 kDa. This protein is mainly expressed in infected liver cells playing a central role in the virus's life cycle. It forms part of the viral nucleocapsid providing a protective shell for the viral genome. Through its structural role HCV Core Protein ensures the stability and integrity of the viral particles necessary for efficient infection and replication.
Biological function summary

The Hepatitis C Virus Core Protein influences various cellular processes. It interacts with host cell signaling pathways and cellular structures to facilitate viral replication. As part of a larger proteins complex the core protein contributes to the production of virus particles. Moreover it possesses regulatory roles that impact gene transcription and modulation of host cell immune responses further aiding viral propagation and persistence within the host.

Pathways

Studies show that HCV Core Protein is involved in disrupting normal cellular pathways such as the PI3K-Akt pathway which is significant for cell survival and anti-apoptosis mechanisms. It interacts with proteins like p53 and Bcl-2 which further link to the JAK-STAT pathway involved in immune modulation. These interactions illustrate how the core protein manipulates host cell environments to benefit viral survival and replication while potentially triggering pathogenic pathways within the host.

The Hepatitis C Virus Core Protein holds connections to liver diseases notably chronic hepatitis and hepatocellular carcinoma. These conditions arise from the persistent infection and the core protein's interference with apoptotic and immune pathways contributing to carcinogenesis. It relates closely with other viral proteins like NS5A which together exacerbate liver fibrosis and cancer development. The core protein's pathogenic role highlights its interest as a target for anti-HCV therapies potentially guiding therapeutic antibody development against hepatitis C like anti-HCV core antibodies or anti-hepatitis C antibodies.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (99)

Recent publications for all applications. Explore the full list and refine your search

International journal of biological sciences 21:802-822 PubMed39781468

2025

Tubulointerstitial nephritis antigen-like 1 promotes the progression of liver fibrosis after HCV eradication with direct-acting antivirals.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Lei,Hu Li,Xue-Kai Wang,Jian-Rui Li,Han Sun,Hong-Ying Li,Jia-Yu Li,Mei Tang,Jing-Chen Xu,Biao Dong,Yue Gong,Dan-Qing Song,Jian-Dong Jiang,Zong-Gen Peng

Autophagy 20:2238-2254 PubMed38842055

2024

ATG10S promotes IFNL1 expression and autophagic degradation of multiple viral proteins mediated by IFNL1.

Applications

Unspecified application

Species

Unspecified reactive species

Miao-Qing Zhang,Jian-Rui Li,Lu Yang,Zong-Gen Peng,Shuo Wu,Jing-Pu Zhang

Acta pharmaceutica Sinica. B 14:2520-2536 PubMed38828143

2024

Interferon-induced MXB protein restricts vimentin-dependent viral infection.

Applications

Unspecified application

Species

Unspecified reactive species

Dongrong Yi,Ni An,Quanjie Li,Qian Liu,Huihan Shao,Rui Zhou,Jing Wang,Yongxin Zhang,Ling Ma,Fei Guo,Xiaoyu Li,Zhenlong Liu,Shan Cen

PloS one 19:e0303265 PubMed38739590

2024

Immortalized hepatocyte-like cells: A competent hepatocyte model for studying clinical HCV isolate infection.

Applications

Unspecified application

Species

Unspecified reactive species

Yongyut Pewkliang,Piyanoot Thongsri,Phichaya Suthivanich,Nipa Thongbaiphet,Jiraporn Keatkla,Ekawat Pasomsub,Usanarat Anurathapan,Suparerk Borwornpinyo,Adisak Wongkajornsilp,Suradej Hongeng,Khanit Sa-Ngiamsuntorn

Nature communications 15:652 PubMed38253527

2024

EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses.

Applications

Unspecified application

Species

Unspecified reactive species

Qiu Pan,Yan Xie,Ying Zhang,Xinqi Guo,Jing Wang,Min Liu,Xiao-Lian Zhang

PLoS pathogens 19:e1011552 PubMed37540723

2023

Hepatitis C virus non-structural proteins modulate cellular kinases for increased cytoplasmic abundance of host factor HuR and facilitate viral replication.

Applications

Unspecified application

Species

Unspecified reactive species

Harsha Raheja,Biju George,Sachin Kumar Tripathi,Sandhini Saha,Tushar Kanti Maiti,Saumitra Das

Avicenna journal of medical biotechnology 15:173-179 PubMed37538239

2023

Expression of the Hepatitis C Virus core-NS3 Fusion Protein on the Surface of Bacterial Ghosts: Prospects for Vaccine Production.

Applications

Unspecified application

Species

Unspecified reactive species

Minoosadat Tayebinia,Sedigheh Sharifzadeh,Gholamreza Rafiei Dehbidi,Farahnaz Zare,Reza Ranjbaran,Amir Rahimi,Mohammad Reza Miri,Mehdi Mirzakhani,Abbas Behzad-Behbahania

Frontiers in immunology 13:1007718 PubMed36532074

2022

Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Ni An,Qinghua Ge,Huihan Shao,Quanjie Li,Fei Guo,Chen Liang,Xiaoyu Li,Dongrong Yi,Long Yang,Shan Cen

Virology journal 19:118 PubMed35836293

2022

PPP2R5D promotes hepatitis C virus infection by binding to viral NS5B and enhancing viral RNA replication.

Applications

Unspecified application

Species

Unspecified reactive species

Muhammad Ikram Anwar,Ni Li,Qing Zhou,Mingxiao Chen,Chengguang Hu,Tao Wu,Haihang Chen,Yi-Ping Li,Yuanping Zhou

Virologica Sinica 37:408-417 PubMed35523417

2022

Enhanced host immune responses in presence of HCV facilitate HBV clearance in coinfection.

Applications

Unspecified application

Species

Unspecified reactive species

Shuhui Liu,Kaitao Zhao,Xi Su,Xiaoxiao Gao,Yongxuan Yao,Ranran Kong,Yun Wang,Chunchen Wu,Mengji Lu,Xinwen Chen,Rongjuan Pei
View all publications

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