Anti-Hepatitis E Virus antibody [5F3]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Hepatitis E virus (HEV) is a non-enveloped RNA virus with a genome that encodes three open reading frames. The mass of the virus particle has not been explicitly determined due to its virus nature but it comprises several proteins including the capsid protein which is essential for virion assembly. HEV predominantly expresses in the liver as this organ serves as the primary site for its replication. Commonly researchers refer to hepatitis E virus by its abbreviation HEV in scientific literature.

Biological function summary

HEV impacts liver function through its replication within hepatocytes contributing to liver inflammation and damage. The virus does not form a complex with other viral components but relies on host cell machinery for its replication cycle. Hepatitis E antibodies including anti-HEV and HEV antibodies such as 5f3 can target the virus for immune recognition and clearance with the immune response playing an important role in controlling and eliminating the infection.

Pathways

The virus integrates into the immune signaling pathways associated with viral recognition and response. HEV interacts with innate immune pathways to subvert the host's defense mechanisms. The interferon pathway is particularly significant in moderating the viral life cycle and proteins such as interferon-stimulated genes (ISGs) become upregulated in response to HEV presence. Additionally interactions with proteins within the apoptotic pathway may contribute to virus-induced cellular responses influencing both cell survival and antiviral defense.

Associated diseases and disorders

HEV is primarily linked to hepatitis E an acute liver disease with symptoms such as jaundice fatigue and nausea. This condition can become more severe in pregnant women leading to maternal mortality. HEV infection can also escalate into chronic hepatitis particularly in immunocompromised individuals. In chronic cases the virus associates with proteins involved in the liver fibrosis process potentially contributing to long-term liver damage and cirrhosis. Current research continues to explore the relationship between hepatitis E antibodies and the modulation of disease outcomes.