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Rabbit Polyclonal HERPUD1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HERPUD1 aa 1-300.

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Images

Western blot - Anti-HERPUD1 antibody (AB155778), expandable thumbnail
  • Western blot - Anti-HERPUD1 antibody (AB155778), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERPUD1 antibody (AB155778), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human HERPUD1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q15011

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Mouse
Tested
Expected

Tested
Tested

Species

Mouse

Dilution info

1/1000.00000 - 1/10000.00000

Notes

-

Species

Human

Dilution info

1/1000.00000 - 1/10000.00000

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/1000.00000

Notes

-

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).

Alternative names

Recommended products

Rabbit Polyclonal HERPUD1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HERPUD1 aa 1-300.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human HERPUD1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q15011
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HERPUD1 also known as Herp is a protein involved in the cellular response to stress especially related to the endoplasmic reticulum (ER). It has a molecular mass of approximately 42 kDa. This protein is expressed in various tissues with high expression levels found in the liver heart and muscle. HERPUD1 becomes particularly upregulated during conditions that cause ER stress helping cells manage misfolded proteins.

Biological function summary

HERPUD1 helps maintain cellular homeostasis during periods of ER stress by facilitating the degradation of misfolded proteins. It forms part of a larger complex in the ER-associated degradation (ERAD) pathway which targets these proteins for retrotranslocation and subsequent destruction by the proteasome. HERPUD1 therefore plays a vital role in mitigating the buildup of potentially harmful proteins within the cell.

Pathways

HERPUD1 is integral to the unfolded protein response (UPR) and the ERAD pathway. In the UPR HERPUD1 is involved in signaling mechanisms that help restore normal ER function. It interacts with other proteins such as SEL1L and DERLIN-1 within the ERAD pathway to ensure the proper disposal of misfolded proteins preventing cellular damage.

Associated diseases and disorders

HERPUD1 is connected with neurodegenerative diseases and cardiac disorders. Its dysfunction or dysregulation can lead to the accumulation of misfolded proteins contributing to conditions like Alzheimer's disease. Moreover HERPUD1's relationship with proteins such as ubiquitin suggests its involvement in cardiac stress responses which can be significant in heart failure. HERPUD1's functions and interactions underline its importance in cellular stress responses and associated disease states.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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3 product images

  • Western blot - Anti-HERPUD1 antibody (ab155778), expandable thumbnail

    Western blot - Anti-HERPUD1 antibody (ab155778)

    10% SDS PAGE

    All lanes: Western blot - Anti-HERPUD1 antibody (ab155778) at 1/1000 dilution

    All lanes: Mouse brain whole cell lysate at 50 µg

    Predicted band size: 44 kDa

  • Western blot - Anti-HERPUD1 antibody (ab155778), expandable thumbnail

    Western blot - Anti-HERPUD1 antibody (ab155778)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-HERPUD1 antibody (ab155778) at 1/5000 dilution

    All lanes: 293T whole cell lysate at 30 µg

    Predicted band size: 44 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERPUD1 antibody (ab155778), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERPUD1 antibody (ab155778)

    Immunohistochemical analysis of paraffin-embedded Human U251 xenograft tissue, labeling HERPUD1 with ab155778 at 1/500 dilution.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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