Rabbit Polyclonal HERV-FRD antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ERVFRD-1 aa 1-250.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ERVFRD-1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link P60508
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Chimpanzee | Predicted |
| Cynomolgus monkey | Predicted |
| Gorilla | Predicted |
| Orangutan | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/200.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee, Cynomolgus monkey, Gorilla, Orangutan | Dilution info - | Notes - |
Associated Products
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Target data
Function
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).
Alternative names
ERVFRDE1, UNQ6191/PRO20218, ERVFRD-1, Syncytin-2, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, HERV-FRD_6p24.1 provirus ancestral Env polyprotein
Recommended products
Rabbit Polyclonal HERV-FRD antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ERVFRD-1 aa 1-250.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ERVFRD-1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link P60508
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
HERV-FRD also known as ERVFRD-1 or Syncytin-2 is a protein encoded by the human endogenous retrovirus family F envelope (env) gene. This protein has a molecular mass of approximately 63 kDa. HERV-FRD is strongly expressed in the placenta particularly in the syncytiotrophoblast layer which plays an important role during pregnancy. It functions as an envelope glycoprotein and contributes to cellular fusion processes essential for the formation of syncytiotrophoblasts.
- Biological function summary
HERV-FRD plays an important role in forming syncytiotrophoblasts which are vital for the function of the human placenta. This protein is a component of a larger protein complex that facilitates membrane fusion a critical step in placental development. The fusion process mediated by HERV-FRD is necessary for proper nutrient and gas exchange between the mother and the developing fetus highlighting its role in supporting fetal development.
- Pathways
HERV-FRD interacts with the Syncytin-mediated cell fusion pathway which is important for placental morphogenesis. This protein also interacts with other syncytin proteins like Syncytin-1 which share similar roles in promoting trophoblast fusion. Both proteins derived from different human endogenous retroviruses are integral components of mechanisms that ensure proper placental structure and function.
- Associated diseases and disorders
Abnormalities in HERV-FRD function have been associated with complications such as preeclampsia and certain reproductive failures. Altered expression or function of this protein may affect placental development potentially impacting maternal and fetal health. Additionally HERV-FRD's role in cellular fusion links it indirectly to disorders involving aberrant cell fusion events often seen in certain gestational trophoblastic diseases alongside related proteins such as Syncytin-1.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERV-FRD antibody (ab230198)
Paraffin-embedded human adrenal gland tissue stained for HERV-FRD using ab230198 at 1/100 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERV-FRD antibody (ab230198)
Paraffin-embedded human kidney tissue stained for HERV-FRD using ab230198 at 1/100 dilution in immunohistochemical analysis.
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