AB230198

Anti-HERV-FRD antibody

Name: Anti-HERV-FRD antibody (ab230198) | Abcam
Brand: Abcam Limited
SKU: AB230198

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal HERV-FRD antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ERVFRD-1 aa 1-250.

View Alternative Names

ERVFRDE1, UNQ6191/PRO20218, ERVFRD-1, Syncytin-2, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, HERV-FRD_6p24.1 provirus ancestral Env polyprotein

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERV-FRD antibody (AB230198)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERV-FRD antibody (AB230198)

Paraffin-embedded human adrenal gland tissue stained for HERV-FRD using ab230198 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERV-FRD antibody (AB230198)

Paraffin-embedded human kidney tissue stained for HERV-FRD using ab230198 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ERVFRD-1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P60508

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cynomolgus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HERV-FRD also known as ERVFRD-1 or Syncytin-2 is a protein encoded by the human endogenous retrovirus family F envelope (env) gene. This protein has a molecular mass of approximately 63 kDa. HERV-FRD is strongly expressed in the placenta particularly in the syncytiotrophoblast layer which plays an important role during pregnancy. It functions as an envelope glycoprotein and contributes to cellular fusion processes essential for the formation of syncytiotrophoblasts.

Biological function summary

HERV-FRD plays an important role in forming syncytiotrophoblasts which are vital for the function of the human placenta. This protein is a component of a larger protein complex that facilitates membrane fusion a critical step in placental development. The fusion process mediated by HERV-FRD is necessary for proper nutrient and gas exchange between the mother and the developing fetus highlighting its role in supporting fetal development.

Pathways

HERV-FRD interacts with the Syncytin-mediated cell fusion pathway which is important for placental morphogenesis. This protein also interacts with other syncytin proteins like Syncytin-1 which share similar roles in promoting trophoblast fusion. Both proteins derived from different human endogenous retroviruses are integral components of mechanisms that ensure proper placental structure and function.

Abnormalities in HERV-FRD function have been associated with complications such as preeclampsia and certain reproductive failures. Altered expression or function of this protein may affect placental development potentially impacting maternal and fetal health. Additionally HERV-FRD's role in cellular fusion links it indirectly to disorders involving aberrant cell fusion events often seen in certain gestational trophoblastic diseases alongside related proteins such as Syncytin-1.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed : 18988732).. Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed : 14694139).

See full target information ERVFRD-1

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

ACS omega 9:50622-50633 PubMed39741807

2025

Structure-Function Relationships of the CMP-Sialic Acid Transporter through Analysis of a Pathogenic Variant in an Alternatively Spliced Functional Isoform.

Applications

Unspecified application

Species

Unspecified reactive species

Brenda I Velázquez-Dodge,Marco A Ramírez-Martínez,Nina Pastor,Iván Martínez-Duncker,Yobana Pérez-Cervera,Héctor M Mora-Montes,Blanca E Domínguez-Mendoza,Roberta Salinas-Marín

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HERV-FRD antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERV-FRD antibody (AB230198)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HERV-FRD antibody (AB230198)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise