Anti-HES6 antibody
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(1 Review)
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(1 Publication)
Rabbit Polyclonal HES6 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HES6 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.
View Alternative Names
BHLHB41, HES6, Transcription cofactor HES-6, C-HAIRY1, Class B basic helix-loop-helix protein 41, Hairy and enhancer of split 6, bHLHb41
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HES6 antibody (AB218037)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling HES6 using ab218037 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
Reactivity data
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Supplementary information
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Biological function summary
HES6 influences cell differentiation and the timing of neurogenesis. It does not commonly act as part of a large complex but rather modulates activity by interacting directly with other transcription factors and regulatory proteins. Through these interactions HES6 helps control gene expression patterns important for the development of neural and muscular structures.
Pathways
HES6 participates in the Notch signaling pathway a critical mechanism for cell fate decisions. HES6 interacts with proteins such as HES1 and inhibition of some Notch pathway activities. This interaction influences cell differentiation processes particularly in the nervous system. Another pathway involving HES6 is the Wnt signaling pathway where it acts as a modulator in different cellular contexts though precise mechanical interactions within this pathway continue to be under investigation.
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Publications (1)
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International journal of clinical and experimental 11:99-109 PubMed31938091
2018
Applications
Unspecified application
Species
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