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AB187669

Anti-HESP antibody [EPR12943(2)-44]

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(1 Publication)

Rabbit Recombinant Monoclonal HESP antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.

View Alternative Names

ECRG1, HATL1, HESP, TMPRSS11A, Transmembrane protease serine 11A, Airway trypsin-like protease 1, Epidermal type-II transmembrane serine protease, Esophageal cancer-susceptibility gene 1 protein

2 Images
Western blot - Anti-HESP antibody [EPR12943(2)-44] (AB187669)
  • WB

Supplier Data

Western blot - Anti-HESP antibody [EPR12943(2)-44] (AB187669)

All lanes:

Western blot - Anti-HESP antibody [EPR12943(2)-44] (ab187669) at 1/1000 dilution

Lane 1:

mouse spleen cell lysate at 10 µg

Lane 2:

PC12 cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 48 kDa

false

Western blot - Anti-HESP antibody [EPR12943(2)-44] (AB187669)
  • WB

Supplier Data

Western blot - Anti-HESP antibody [EPR12943(2)-44] (AB187669)

All lanes:

Western blot - Anti-HESP antibody [EPR12943(2)-44] (ab187669) at 1/5000 dilution

Lane 1:

Human fetal liver lysate at 20 µg

Lane 2:

HepG2 cell lysate at 20 µg

Lane 3:

T47D cell lysate at 20 µg

Lane 4:

WI38 cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12943(2)-44

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Hesperetin (HESP) is a small flavonoid with a molecular mass of approximately 302.27 Da. It commonly appears in citrus fruits. This molecule shows significant expression across various plant cells where it functions as both an antioxidant and an anti-inflammatory agent. Hesperetin is also known for its role in modulating enzyme activities affecting several oxidative processes within the cells.
Biological function summary

Hesperetin plays a role in numerous cellular processes. It exhibits its effects mainly through interactions with cellular enzymes affecting the modulation of signal transduction pathways. Hesperetin operates partially within complexes that influence the cell's response to oxidative stress and inflammatory markers. Its ability to interact with these components highlights its importance in maintaining cellular homeostasis and preventing cellular damage.

Pathways

Hesperetin is integral to both the flavonoid biosynthesis and the oxidative stress response pathways. These pathways are vital for reducing reactive oxidative species (ROS) and enhancing the cell's defense mechanisms. In these contexts hesperetin relates to proteins like NADPH oxidase and enzymes involved in the detoxification of ROS. Hesperetin together with these proteins contributes to modulating redox homeostasis within cells.

Hesperetin connects to cardiovascular disease and certain cancers. It helps reduce inflammation and oxidative stress two key factors in the pathogenesis of these conditions. During these disease states hesperetin associates with proteins such as NF-kB and COX-2 both of which play roles in inflammatory pathways. This connection makes HESP a target of interest for therapeutic intervention and research in disease-modifying therapies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
See full target information TMPRSS11A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:5132 PubMed40461535

2025

Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao He,Jiadong Chen,Yan Zhong,Peili Cen,Li Shen,Fei Huang,Jing Wang,Chentao Jin,Rui Zhou,Xiaohui Zhang,Anxin Wang,Jing Fan,Shuang Wu,Mengjiao Tu,Xiyi Qin,Xiaoyun Luo,Yu Zhou,Jieqiao Peng,Youyou Zhou,A Cahid Civelek,Mei Tian,Hong Zhang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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