Anti-HESP antibody [EPR12943(2)-44] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Hesperetin (HESP) is a small flavonoid with a molecular mass of approximately 302.27 Da. It commonly appears in citrus fruits. This molecule shows significant expression across various plant cells where it functions as both an antioxidant and an anti-inflammatory agent. Hesperetin is also known for its role in modulating enzyme activities affecting several oxidative processes within the cells.

Biological function summary

Hesperetin plays a role in numerous cellular processes. It exhibits its effects mainly through interactions with cellular enzymes affecting the modulation of signal transduction pathways. Hesperetin operates partially within complexes that influence the cell's response to oxidative stress and inflammatory markers. Its ability to interact with these components highlights its importance in maintaining cellular homeostasis and preventing cellular damage.

Pathways

Hesperetin is integral to both the flavonoid biosynthesis and the oxidative stress response pathways. These pathways are vital for reducing reactive oxidative species (ROS) and enhancing the cell's defense mechanisms. In these contexts hesperetin relates to proteins like NADPH oxidase and enzymes involved in the detoxification of ROS. Hesperetin together with these proteins contributes to modulating redox homeostasis within cells.

Associated diseases and disorders

Hesperetin connects to cardiovascular disease and certain cancers. It helps reduce inflammation and oxidative stress two key factors in the pathogenesis of these conditions. During these disease states hesperetin associates with proteins such as NF-kB and COX-2 both of which play roles in inflammatory pathways. This connection makes HESP a target of interest for therapeutic intervention and research in disease-modifying therapies.