JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB234979

Anti-HEXIM2 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal HEXIM2 antibody. Suitable for WB, IHC-P and reacts with Rat, Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HEXIM2.

View Alternative Names

L3, HEXIM2, Protein HEXIM2, Hexamethylene bis-acetamide-inducible protein 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEXIM2 antibody (AB234979)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEXIM2 antibody (AB234979)

Paraffin-embedded human testis tissue stained for HEXIM2 with ab234979 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-HEXIM2 antibody (AB234979)
  • WB

Supplier Data

Western blot - Anti-HEXIM2 antibody (AB234979)

All lanes:

Western blot - Anti-HEXIM2 antibody (ab234979) at 1/500 dilution

Lane 1:

Rat liver tissue lysate

Lane 2:

Mouse kidney tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 32 kDa,89 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HEXIM2.

Q96MH2

style
left-column

Alternative Products

Primary Antibodies

AB127710

Anti-HEXIM2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-HEXIM2 antibody (AB127710)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB25388

Anti-HEXIM1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-HEXIM1 antibody (AB25388)

  • 5
  • 2
Primary Antibodies

AB235046

Anti-WDR37 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR37 antibody (AB235046)

  • 0
  • 0
Primary Antibodies

AB237532

Anti-SPTLC3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPTLC3 antibody (AB237532)

  • 0
  • 0
Primary Antibodies

AB234988

Anti-CXX1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXX1 antibody (AB234988)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HEXIM2 also known as Hexamethylene Bisacetamide-Inducible Protein 2 is a protein with a molecular mass of approximately 36 kDa. It functions as a regulatory protein with roles in transcription modulation. HEXIM2 is expressed in various human tissues with notable expression levels in the heart and skeletal muscle. This protein acts as a part of the regulation network that interacts with RNA polymerase II during the transcription process.
Biological function summary

HEXIM2 plays a role in the inhibitory regulation of transcription. It forms part of the 7SK small nuclear ribonucleoprotein (snRNP) complex which is known for controlling the activity of the positive transcription elongation factor b (P-TEFb). This complex regulates RNA polymerase II by inhibiting its transcriptional elongation capability therefore controlling gene expression. The presence of HEXIM2 in this complex indicates its involvement in modulating gene expression through RNA interference pathways.

Pathways

HEXIM2 operates within the transcription elongation regulation pathway and the cell cycle control pathway. In the transcription elongation regulation pathway it contributes significantly to the inhibition of P-TEFb which associates with Cyclin T1 and CDK9. These proteins are vital for allowing RNA polymerase II to proceed with transcription. HEXIM2's involvement ensures the proper timing and modulation of transcriptional activities controlling cellular functions and responses.

HEXIM2 has associations with cancer and cardiac-related conditions. Its role in transcription regulation links it to various forms of cancer where aberrant gene expression is a hallmark. Additionally HEXIM2's expression in cardiac tissues suggests implications in cardiac disorders. Interactions with proteins like Cyclin T1 and CDK9 which are also involved in these conditions highlight potential pathways where HEXIM2 might contribute to disease progression or resistance mechanisms.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed : 15713661, PubMed : 15713662). Core component of the 7SK RNP complex : in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed : 15713661, PubMed : 15713662).
See full target information HEXIM2
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2416590 PubMed40298908

2025

Nuclear-Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Haiying Liu,Jiaqian Feng,Tingting Pan,Pinggen Zhang,Ling Ye,Zetan Jiang,Zilong Zhou,Qiankun Mao,Jian Li,Xinyi Yang,Ping Gao,De Huang,Huafeng Zhang
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com