Rabbit Polyclonal HEXO antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ERI1 aa 1-100.
View Alternative Names
3'EXO, THEX1, 3`EXO, ERI1, 3'-5' exoribonuclease 1, 3'-5' exonuclease ERI1, Eri-1 homolog, Histone mRNA 3'-end-specific exoribonuclease, Histone mRNA 3'-exonuclease 1, Protein 3'hExo, HEXO
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEXO antibody (AB236945)
Paraffin-embedded human testis tissue stained for HEXO using ab236945 at 1/400 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-HEXO antibody (AB236945)
4% formaldehyde-fixed, 0.2% Triton X-100 permeabilized HepG2 (human liver hepatocellular carcinoma cell line) cells stained for HEXO (green) using ab236945 at 1/133 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L). Counter-stained with DAPI.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEXO antibody (AB236945)
Paraffin-embedded human small intestine tissue stained for HEXO using ab236945 at 1/400 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Biological function summary
HEXO is significant in energy metabolism. It converts glucose into glucose-6-phosphate setting off the glycolytic pathway and linking to other pathways such as the pentose phosphate pathway. HEXO often functions as part of a larger enzyme complex within the cell collaborating with other glycolytic enzymes to efficiently metabolize glucose. Its activity influences cellular energy homeostasis and biosynthetic processes impacting cellular growth and division.
Pathways
HEXO is a central enzyme in carbohydrate metabolism and plays an important role in the glycolysis and pentose phosphate pathways. In glycolysis HEXO catalyzes the first committed step which is important for the production of ATP and metabolic intermediates. In the pentose phosphate pathway it provides glucose-6-phosphate as a substrate which is essential for the generation of NADPH and ribose-5-phosphate. Proteins like Glucose-6-phosphate dehydrogenase (G6PD) work with HEXO in the pentose phosphate pathway showcasing a collaborative role in oxidative stress response and anaplerotic reactions.
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Publications (1)
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iScience 28:112748 PubMed40585507
2025
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Unspecified application
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