Anti-HEY2 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

'HEY2' also known as 'heart and neural crest derivatives-expressed protein 2' or simply 'HEY’ or 'heytwo' is a transcription factor from the hairy and enhancer of split (HES) family. This protein has a molecular mass of approximately 37 kDa. It plays a significant role in the regulation of gene expression by binding to specific sequences in DNA. 'HEY2' gets expressed in different tissues particularly in heart vascular and neural crest-derived cells. Its expression appears during various stages of development and remains present in certain adult tissues underlining its continuing importance in cellular function.

Biological function summary

'HEY2' participates in the regulation of cell differentiation and proliferation. It functions within the Notch signaling pathway and often associates with transcriptional repression complexes. 'HEY2' has the ability to modulate the activity of other transcription factors by influencing their binding efficiency. Through these interactions it helps establish cellular identities and maintain the balance between cell populations within developing tissues. Its involvement in cardiovascular development among others stands as a testament to its functional diversity.

Pathways

This protein occupies an important position in the Notch signaling pathway and the TGF-beta signaling pathway. Within the Notch pathway 'HEY2' functions as a downstream effector that transduces signals necessary for cell fate determination. It is related closely to other Notch signaling components like JAG1 and DLL4. Additionally the interaction with the TGF-beta signaling pathway provides a link to cellular processes like apoptosis and epithelial-mesenchymal transition although the precise mechanisms demand further exploration.

Mutations and aberrant expression levels of 'HEY2' have been associated with congenital heart defects and cardiomyopathies. Its involvement with congenital heart defects is often observed with other proteins in the Notch pathway such as NOTCH1. Researchers find connections between 'HEY2' expressions and specific cardiovascular pathologies indicating its potential as a target for therapeutic interventions. Involvement in these conditions emphasizes the necessity for more detailed studies of this protein's behavior under pathological conditions.