Anti-HFBI antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HFBI also known as hydrophobin I is a small protein with a molecular mass of approximately 7-9 kDa. It occurs in certain fungal species where it plays a role in forming hydrophobic surfaces. In certain fungi this protein expresses on both the cell wall and secreted materials. HFBI creates a water-repellent layer that facilitates the interactions between the fungus and its environment contributing to processes like spore dispersal and fungal growth.

Biological function summary

HFBI functions in forming membranes that involve interactions with hydrophobic structures. It does not occur as part of a larger complex but instead acts independently or in a coordination with other hydrophobins. Its ability to self-assemble into structures with surface activity allows it to contribute to the defense of the fungus by providing a protective barrier. This surface modification has significant implications for the adaptation and survival of fungi in various environments.

Pathways

HFBI contributes to processes like surface adhesion and developmental pathways unique to fungal species. While it is not directly involved in major mammalian signaling pathways it can be connected to processes involving cell wall biosynthesis and interactions related to other hydrophobins such as HFBII. These pathways reflect its roles in maintaining fungal cell structure and forming protective hydrophobic layers which are important for fungal physiology.

Associated diseases and disorders

HFBI relates to pathologies in humans mainly through its involvement in certain fungal infections. Pathogenic fungi that express HFBI like Trichoderma species may cause diseases in immunocompromised individuals. During these infections HFBI helps form robust protective barriers hindering immune system access. HFBI interacts with other fungal proteins potentially including enzymes like chitinase that are important during the disease progression by destabilizing host tissues. Understanding HFBI's role in these fungi may help develop better strategies for managing fungal infections.