AB279373

Anti-HHLA3 antibody [OTI10B4]

Name: Anti-HHLA3 antibody [OTI10B4] (ab279373) | Abcam
Brand: Abcam Limited
SKU: AB279373

Be the first to review this product! Submit a review

(1 Publication)

Mouse Monoclonal HHLA3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ANKRD13C-DT.

View Alternative Names

HHLA3, ANKRD13C-DT, Putative uncharacterized protein ANKRD13C-DT, ANKRD13C divergent transcript, HERV-H LTR-associating protein 3, Human endogenous retrovirus-H long terminal repeat-associating protein 3, HERV-H LTR-associating 3, HERV H LTR associating protein 3, Human endogenous retrovirus-H long terminal repeat-associating 3, Human endogenous retrovirus H long terminal repeat associating protein 3

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA3 antibody [OTI10B4] (AB279373)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA3 antibody [OTI10B4] (AB279373)

Paraffin embedded human liver tissue stained for HHLA3 using ab279373 at 1/500 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA3 antibody [OTI10B4] (AB279373)

Paraffin embedded human kidney tissue stained for HHLA3 using ab279373 at 1/500 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA3 antibody [OTI10B4] (AB279373)

Paraffin embedded human lymphoma tissue stained for HHLA3 using ab279373 at 1/500 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA3 antibody [OTI10B4] (AB279373)

Paraffin embedded carcinoma of human thyroid tissue stained for HHLA3 using ab279373 at 1/500 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI10B4

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ANKRD13C-DT.

Q9XRX5

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HHLA3 also known as Human Endogenous Retrovirus (HERV)-H Long Terminal Repeat-Associating protein 3 is a cell surface protein with a predicted mass of approximately 32 kDa. This protein is a member of the B7 family which plays a role in immune regulation. HHLA3 is expressed in a range of tissue types with high levels in the placenta and moderate levels in peripheral blood mononuclear cells (PBMCs). Its expression pattern indicates potential involvement in immune system processes.

Biological function summary

HHLA3 functions in immune modulation and may inhibit T-cell responses. Researchers have yet to confirm its participation in protein complexes but interactions with other B7 family proteins suggest a potential role. These interactions possibly regulate immune checkpoints which control immune response strength and are important for preventing autoimmunity and maintaining self-tolerance.

Pathways

Researchers find HHLA3 relevant to the immune checkpoint pathways and T-cell receptor signaling. Through these pathways HHLA3 might influence the activation and inhibition of T-cells. It potentially cooperate with other immune checkpoints like PD-L1 and CTLA-4 involving itself in the modulation of the immune responses and determining the immune system's balance between activation and inhibition.

HHLA3 has connections to cancer and autoimmune diseases. Research suggests its expression may correlate with tumor immune evasion strategies suggesting potential as a target for cancer immunotherapy. In autoimmune diseases its regulatory role implies interaction with proteins such as CTLA-4 influencing immune responses and self-tolerance. Further studies will continue to develop understanding of its implications in these areas hoping to uncover new therapeutic strategies.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

See full target information ANKRD13C-DT

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC medicine 22:19 PubMed38191448

2024

LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hongjin Shi,Zhiyong Tan,Bowen Duan,Chunming Guo,Chong Li,Ting Luan,Ning Li,Yinglong Huang,Shi Chen,Jixian Gao,Wei Feng,Haole Xu,Jiansong Wang,Shi Fu,Haifeng Wang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HHLA3 antibody [OTI10B4]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA3 antibody [OTI10B4] (AB279373)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA3 antibody [OTI10B4] (AB279373)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA3 antibody [OTI10B4] (AB279373)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA3 antibody [OTI10B4] (AB279373)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise