AB128404

Anti-HHV6 antibody [C3108-103]

Name: Anti-HHV6 antibody [C3108-103] (ab128404) | Abcam
Brand: Abcam Limited
SKU: AB128404
Price: 535 USD
Availability: InStock

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(5 Publications)

Mouse Monoclonal HHV6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human betaherpesvirus 6 samples. Cited in 5 publications.

View Alternative Names

Herpes Virus 6, Herpes Virus Type 6

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C3108-103

Isotype

IgG1

Light chain type

kappa

Carrier free

Reacts with

Human betaherpesvirus 6

Applications

IHC-P, ICC/IF

applications

Specificity

Human herpes virus 6, B variant. Recognises a viron protein of 101 kD. Gives a cytoplasmic speckled pattern in IF.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human betaherpesvirus 6": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/25 - 1/100", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle|Store undiluted

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HHV-6 also known as Human Herpesvirus 6 is a DNA virus with a double-stranded genome and an icosahedral capsid. The alternate name for this virus is Roseolovirus. It expresses in various human tissues especially in peripheral blood mononuclear cells and is a member of the Herpesviridae family. The virion size of HHV-6 is about 200 nm. HHV-6 antibodies like HHV-6 IgG are useful for diagnosing infections in the laboratory setting.

Biological function summary

HHV-6 targets immune cells particularly T lymphocytes and integrates its genome into the host’s DNA where it establishes a latent infection. This virus does not usually form part of a complex. However it can reactivate in conditions where the immune system is compromised such as in individuals undergoing immunosuppressive therapy. HHV-6 influences the function of the immune system and impacts the host's cellular environment through modulation of cytokine expression.

Pathways

The virus impacts immune modulation pathways particularly by affecting the IL-6 signaling pathway. Its interaction with the host's immune response influences not only cytokines but also relations with proteins like CD46 which HHV-6 uses as a cellular receptor for entry into human cells. By engaging these pathways HHV-6 plays a direct role in lymphocyte function and immune evasion.

HHV-6 is linked to conditions such as roseola infantum causing fever and rash in young children and has been associated with more severe conditions like encephalitis in immunocompromised individuals. The virus’s connection with diseases ties to its influence on proteins within the immune system including triggering alterations in cytokine profiles that may worsen the disease outcome.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information HHV6

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 10: PubMed40956617

2025

miR147 promotes mucosal integrity and healing in intestinal inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Agnieszka K Czopik,Arash Dabiri,Chia-Hao Tung,Victoria Vaughn,Xiangsheng Huang,Jinlian Wang,Hui Li,Nicolas F Moreno,Natalia V Piwko,Katherine Figarella,Hongfang Liu,Zhongming Zhao,Xiaoyi Yuan,Holger K Eltzschig

Journal of asthma and allergy 18:655-664 PubMed40322735

2025

Carbamazepine-Induced DRESS Complicated by HLH and VBDS: A Case Report.

Applications

Unspecified application

Species

Unspecified reactive species

Hanyue Zhang,Pan Jiang,Sibin Mei,Ne Lin,Yanfei Fang,Qian Cao

Nature 617:564-573 PubMed36996872

2023

Genomic investigations of unexplained acute hepatitis in children.

Applications

Unspecified application

Species

Unspecified reactive species

Sofia Morfopoulou,Sarah Buddle,Oscar Enrique Torres Montaguth,Laura Atkinson,José Afonso Guerra-Assunção,Mahdi Moradi Marjaneh,Riccardo Zennezini Chiozzi,Nathaniel Storey,Luis Campos,J Ciaran Hutchinson,John R Counsell,Gabriele Pollara,Sunando Roy,Cristina Venturini,Juan F Antinao Diaz,Ala'a Siam,Luke J Tappouni,Zeinab Asgarian,Joanne Ng,Killian S Hanlon,Alexander Lennon,Andrew McArdle,Agata Czap,Joshua Rosenheim,Catarina Andrade,Glenn Anderson,Jack C D Lee,Rachel Williams,Charlotte A Williams,Helena Tutill,Nadua Bayzid,Luz Marina Martin Bernal,Hannah Macpherson,Kylie-Ann Montgomery,Catherine Moore,Kate Templeton,Claire Neill,Matt Holden,Rory Gunson,Samantha J Shepherd,Priyen Shah,Samantha Cooray,Marie Voice,Michael Steele,Colin Fink,Thomas E Whittaker,Giorgia Santilli,Paul Gissen,Benedikt B Kaufer,Jana Reich,Julien Andreani,Peter Simmonds,Dimah K Alrabiah,Sergi Castellano,Primrose Chikowore,Miranda Odam,Tommy Rampling,Catherine Houlihan,Katja Hoschler,Tiina Talts,Cristina Celma,Suam Gonzalez,Eileen Gallagher,Ruth Simmons,Conall Watson,Sema Mandal,Maria Zambon,Meera Chand,James Hatcher,Surjo De,Kenneth Baillie,Malcolm Gracie Semple,Joanne Martin,Ines Ushiro-Lumb,Mahdad Noursadeghi,Maesha Deheragoda,Nedim Hadzic,Tassos Grammatikopoulos,Rachel Brown,Chayarani Kelgeri,Konstantinos Thalassinos,Simon N Waddington,Thomas S Jacques,Emma Thomson,Michael Levin,Julianne R Brown,Judith Breuer

Biomolecules 10: PubMed33172107

2020

The Presence of Human Herpesvirus 6 in the Brain in Health and Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Gabriel Santpere,Marco Telford,Pol Andrés-Benito,Arcadi Navarro,Isidre Ferrer

Virologica Sinica 33:402-409 PubMed30374827

2018

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis.

Applications

Unspecified application

Species

Unspecified reactive species

Dong Liu,Xin Wang,Yisong Wang,Peigang Wang,Dongying Fan,Sichang Chen,Yuguang Guan,Tianfu Li,Jing An,Guoming Luan

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-HHV6 antibody [C3108-103]

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Specificity

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise