Anti-HHV8 antibody [LN53]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

HHV-8 disrupts normal cellular processes by expressing proteins like LANA (latency-associated nuclear antigen) that interfere with host cellular mechanisms. It is known to be part of complex interactions within infected cells chiefly affecting the tumor suppressor pathways. These proteins lead to changes that permit the infected cells to escape immune destruction and continue proliferating unchecked. Despite interventions the virus maintains a dormant state in the host which makes complete eradication difficult.

Pathways

HHV-8 influences two major biological pathways—the p53 signaling pathway and the NF-kB signaling pathway. The virus's interference with the p53 protein which plays a critical role in controlling cell cycle arrest and apoptosis is a major aspect of its pathogenic capacity. Additionally HHV-8 can activate the NF-kB pathway which leads to inflammation and survival signaling encouraging oncogenic transformation. This viral manipulation disrupts normal cellular homeostasis and contributes to disease manifestation.