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AB181050

Anti-HIAT1 antibody [EPR9642]

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(1 Publication)

Rabbit Recombinant Monoclonal HIAT1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

HIAT1, MFSD14A, Solute carrier family 71 member 1, Hippocampus abundant transcript 1 protein, Major facilitator superfamily domain-containing 14A, Putative tetracycline transporter-like protein

1 Images
Western blot - Anti-HIAT1 antibody [EPR9642] (AB181050)
  • WB

Supplier Data

Western blot - Anti-HIAT1 antibody [EPR9642] (AB181050)

All lanes:

Western blot - Anti-HIAT1 antibody [EPR9642] (ab181050) at 1/10000 dilution

All lanes:

Human fetal brain lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab136636'>ab136636</a>) at 1/1000 dilution

Predicted band size: 53 kDa

false

  • Carrier free

    Anti-HIAT1 antibody [EPR9642] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9642

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HIAT1 also known as hippocampus abundant transcript 1 protein is a transmembrane protein with a mass of approximately 28 kDa. This protein is located in the cell membrane and shows expression in various tissues but it is more abundant in the brain especially within the hippocampus. Research shows that HIAT1 participates in regulating ion transport across the cell membrane which is important for maintaining cellular homeostasis.
Biological function summary

This protein plays a role in neuronal function and development. It is part of a larger molecular complex that influences synaptic transmission and plasticity. HIAT1 has a significant impact on neuronal signaling by interacting with specific receptors and ion channels. This involvement suggests that the protein has a potential influence on learning and memory processes reflecting its expression pattern in the brain.

Pathways

HIAT1 significantly engages in neural communication pathways that are critical for brain function. It interacts with the glutamatergic signaling pathway which is essential for excitatory synaptic transmission. Connections exist between HIAT1 and other proteins like NMDA receptors contributing to synapse modulation and neuronal excitability. Additionally HIAT1 may influence the calcium signaling pathway to affect cellular responses to stimuli.

Disruptions or alterations in HIAT1 expression have been linked to neurological conditions such as epilepsy and Alzheimer's disease. Abnormal HIAT1 function may affect proteins like amyloid precursor protein (APP) highlighting its potential role in the pathogenesis of Alzheimer's. In epilepsy changes in HIAT1 might contribute to altered neuronal excitability suggesting its involvement in the disease's development and progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable membrane-bound transporter. May play a role in neuronal nutrient sensing and energy homeostasis. Required for the final stages of spermatogenesis.
See full target information MFSD14A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2400253 PubMed39119847

2024

Homeostatic Shrinkage of Dendritic Spines Requires Melatonin Type 3 Receptor Activation During Sleep.

Applications

Unspecified application

Species

Unspecified reactive species

Shiyin Li,Xin Li,Minmin Lu,Quanhui Chen,Di Yao,Xiaoqian Yu,Zhen Li,Woo-Ping Ge,Na Wang,Jiehua Jin,Yaling Wang,Yixiang Liao,Fenlan Luo,Jie Yan,Xuedan Chen,Chenggang Jiang,Faguo Yue,Dong Gao,Xiangdong Tang,Hong Guo,Yanjiang Wang,Xiaowei Chen,Jianxia Xia,Min Xu,Shuancheng Ren,Chao He,Zhian Hu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com