Anti-HIAT1 antibody [EPR9642]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HIAT1 also known as hippocampus abundant transcript 1 protein is a transmembrane protein with a mass of approximately 28 kDa. This protein is located in the cell membrane and shows expression in various tissues but it is more abundant in the brain especially within the hippocampus. Research shows that HIAT1 participates in regulating ion transport across the cell membrane which is important for maintaining cellular homeostasis.

Biological function summary

This protein plays a role in neuronal function and development. It is part of a larger molecular complex that influences synaptic transmission and plasticity. HIAT1 has a significant impact on neuronal signaling by interacting with specific receptors and ion channels. This involvement suggests that the protein has a potential influence on learning and memory processes reflecting its expression pattern in the brain.

Pathways

HIAT1 significantly engages in neural communication pathways that are critical for brain function. It interacts with the glutamatergic signaling pathway which is essential for excitatory synaptic transmission. Connections exist between HIAT1 and other proteins like NMDA receptors contributing to synapse modulation and neuronal excitability. Additionally HIAT1 may influence the calcium signaling pathway to affect cellular responses to stimuli.

Associated diseases and disorders

Disruptions or alterations in HIAT1 expression have been linked to neurological conditions such as epilepsy and Alzheimer's disease. Abnormal HIAT1 function may affect proteins like amyloid precursor protein (APP) highlighting its potential role in the pathogenesis of Alzheimer's. In epilepsy changes in HIAT1 might contribute to altered neuronal excitability suggesting its involvement in the disease's development and progression.