Rabbit Polyclonal HIC1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HIC1 aa 250-450.
View Alternative Names
ZBTB29, HIC1, Hypermethylated in cancer 1 protein, Hic-1, Zinc finger and BTB domain-containing protein 29
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HIC1 antibody (AB235037)
Paraffin-embedded human endometrial cancer tissue stained for HIC1 using ab235037 at 1/400 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HIC1 antibody (AB235037)
Paraffin-embedded human breast cancer tissue stained for HIC1 using ab235037 at 1/400 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Reactivity data
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Supplementary information
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Biological function summary
The HIC1 protein contributes to the repression of gene activity by binding to specific DNA sequences. It forms a part of chromatin remodeling complexes influencing chromatin structure and impacting transcription regulation. HIC1 interacts with other proteins like CtBP to carry out its functions effectively. Its ability to modulate gene expression makes HIC1 an important player in maintaining normal cell proliferation and differentiation pathways.
Pathways
HIC1 importantly integrates into the tumor suppression and cellular senescence pathways. It has strong associations within the p53 pathway which is central to controlling the cell cycle and promoting apoptosis. The interaction of HIC1 with proteins such as p53 and SIRT1 showcases its role in these pathways where it helps regulate gene expression that curtails tumor growth and enhances cellular longevity.
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Publications (1)
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Redox biology 24:101211 PubMed31108460
2019
Applications
Unspecified application
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Unspecified reactive species
Product promise
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