Anti-HIF3 alpha/IPAS antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HIF3 alpha also known as IPAS stands as a unique member of the hypoxia-inducible factor (HIF) family involved in oxygen regulation. HIF3 alpha is a transcription factor made of approximately 66 kDa protein mass which plays a role in controlling gene expression in response to low oxygen conditions. It gets expressed in various tissues including the brain lungs and kidneys. Unlike HIF1 alpha and HIF2 alpha HIF3 alpha can act as negative regulator of HIF-mediated gene activation by forming complexes with other HIFs impeding their transcriptional ability.

Biological function summary

HIF3 alpha engages in cellular response to hypoxic environments by binding to hypoxia-responsive elements in DNA. It forms heterodimers with ARNT an aryl hydrocarbon receptor nuclear translocator allowing interaction with DNA sequences needed for hypoxia response. HIF3 alpha differs by sometimes inhibiting rather than activating target genes providing a balance to the functions of other HIFs. It affects vascular development and energy metabolism performing roles outside traditional hypoxia response.

Pathways

HIF3 alpha integrates into key biological networks such as the HIF signaling pathway and oxygen homeostasis. Within these pathways it interacts with other HIF family members including HIF1 alpha and HIF2 alpha regulating downstream hypoxia-adaptive responses. This interaction allows a fine-tuned balance in the expression of genes linked to angiogenesis and erythropoiesis exemplifying its antagonistic function in comparison to other HIFs that usually activate these pathways.

Associated diseases and disorders

HIF3 alpha assumes significant roles in the context of conditions like non-small cell lung carcinoma (NSCLC) and sleep apnea. Studies suggest alterations in HIF3 alpha expression contribute to tumor progression in NSCLC and the regulation of respiratory drive under low oxygen conditions in sleep apnea. Through these disease processes potential connections with proteins like VEGF (Vascular Endothelial Growth Factor) underline HIF3 alpha's modulatory impact in angiogenic activity and hypoxic responses affecting disease progression and outcomes.