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AB252976

Anti-HIG2 antibody

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Rabbit Polyclonal HIG2 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human HILPDA aa 1 to C-terminus.

View Alternative Names

C7orf68, HIG2, HILPDA, Hypoxia-inducible lipid droplet-associated protein, Hypoxia-inducible gene 2 protein

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-HIG2 antibody (AB252976)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HIG2 antibody (AB252976)

PFA-fixed, Triton X-100 permeabilized A549 (Human lung carcinoma cell line) cells stained for HIG2 (green) using ab252976 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human HILPDA aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5L2

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HIG2 also known as Hypoxia-Inducible Gene 2 is a protein involved in lipid metabolism. HIG2 has a molecular mass of approximately 79 kDa. It is expressed in various tissues with elevated levels in adipose tissue and several cancer types. The protein plays an important role in the regulation of lipid droplet formation and energy balance within the cells making it an interesting target of study for metabolic and cancer research.
Biological function summary

HIG2 is known to interact with other proteins involved in lipid metabolism. It does not function as part of a complex but influences the storage and mobilization of fats within cells. HIG2 expression can increase in response to hypoxic conditions which often occur in the tumor microenvironment. This association with hypoxia suggests its involvement not only in metabolism but also in cancer biology.

Pathways

HIG2 integrates into lipid metabolism and hypoxia response pathways. It interacts with proteins such as perilipin-1 on lipid droplets and others within the fatty acid metabolism pathway. Through these interactions HIG2 contributes to the homeostasis of lipids affecting how cells store and utilize energy under varying oxygen levels. The protein's modulation of lipid storage aligns it with mechanisms that cells use to adapt to hypoxic conditions which often occur in tumors or adipose tissues.

HIG2 is most closely associated with cancer and obesity. Changes in its expression levels can influence tumor growth particularly in cancers that depend on lipid metabolism for energy supply. In obesity abnormal regulation of HIG2 may disrupt normal adipose tissue function contributing to metabolic syndrome. HIG2's connection to such conditions often involves its interaction with proteins like HIF-1 alpha a regulator of the hypoxic response which can exacerbate the progression of these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
See full target information HILPDA
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Product promise

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