Anti-HIGD2A antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HIGD2A also known as HIG1 hypoxia-inducible domain family member 2A is a protein with a mass of approximately 11 kDa. It plays a mechanical role as an accessory protein in mitochondrial function. Primarily researchers find its expression in the mitochondria of various tissues where it seems to stabilize cellular energy processes under stress. Beyond its common identification as HIGD2A the protein also appears in scientific literature linked to mitochondrial activity and response to low oxygen levels.

Biological function summary

HIGD2A interacts with several components of the mitochondrial respiratory chain. This protein becomes particularly active during hypoxic conditions to help maintain cellular energy production. It forms part of a complex with other mitochondrial proteins which helps protect the network integrity of mitochondria. These actions ensure that HIGD2A supports cell survival during energy shortage conditions and aids in regulating metabolic responses to such changes.

Pathways

This protein fits integrally into both the hypoxia and apoptosis pathways. In the hypoxia pathway HIGD2A works alongside hypoxia-inducible factors to adjust cellular metabolism under low oxygen availability. In the apoptosis pathway its interactions with proteins like cytochrome c link it to roles in controlling cell death. These pathways highlight how HIGD2A aids in balancing processes important for cellular adaptation and survival under stress conditions.

Associated diseases and disorders

HIGD2A has associations with conditions including ischemia and neurodegenerative diseases. In ischemia its ability to enhance mitochondrial stability helps minimize damage from reduced blood flow. In neurodegenerative diseases the protective role of HIGD2A may mitigate mitochondrial dysfunction a common feature of such disorders. Researchers also study its interactions with other mitochondrial proteins like HIGD1A to understand the complexities of its contributions to disease pathways.