JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB198802

Anti-HIPK1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal HIPK1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HIPK1.

View Alternative Names

KIAA0630, MYAK, NBAK2, HIPK1, Homeodomain-interacting protein kinase 1, Nuclear body-associated kinase 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HIPK1 antibody (AB198802)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HIPK1 antibody (AB198802)

Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling HIPK1 with ab198802 at 1/25 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HIPK1 antibody (AB198802)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HIPK1 antibody (AB198802)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling HIPK1 with ab198802 at 1/25 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human HIPK1. The exact immunogen used to generate this antibody is proprietary information.

Q86Z02

style
left-column

Complementary Products

Primary Antibodies

AB309096

Anti-METTL14 antibody [EPR27234-62]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-METTL14 antibody [EPR27234-62] (AB309096)

  • 0
  • 0
Primary Antibodies

AB284792

Anti-RAP1A antibody [EP878] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-RAP1A antibody [EP878] - BSA and Azide free (AB284792)

  • 0
  • 0
Primary Antibodies

AB76109

Anti-MMP20 antibody [EP1275Y]

RabMAb|Recombinant

Western blot - Anti-MMP20 antibody [EP1275Y] (AB76109)

  • 0
  • 0
Primary Antibodies

AB197690

Anti-KLF7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF7 antibody (AB197690)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HIPK1 also known as Homeodomain-Interacting Protein Kinase 1 functions as a serine/threonine kinase. It has a molecular mass of approximately 132 kDa. This protein acts in the regulation of transcription factors and apoptosis. HIPK1 is widely expressed with higher levels in the brain heart and lung tissues. Researchers sometimes investigate its roles in several signal transduction pathways due to its regulatory functions.
Biological function summary

HIPK1 participates in various cellular processes including apoptosis DNA damage response and Wnt signaling. It forms complexes with several transcription factors such as p53 and Smad proteins modifying their activity to influence cell fate. By interacting with transcription regulators HIPK1 modulates gene expression and has implications in cell growth and differentiation.

Pathways

HIPK1 interacts with proteins in important signaling cascades including the Wnt and JNK pathways. Notably HIPK1 phosphorylates components like c-Jun influencing the JNK pathway's role in stress response and apoptosis. Additionally in the Wnt pathway HIPK1 modulates β-catenin signaling which is important for regulating cell proliferation and differentiation. These interactions connect HIPK1 to wider cellular communications and responses.

Researchers have linked HIPK1 to cancer and fibrotic diseases. Abnormal HIPK1 expression or activity can influence oncogenic processes due to its regulatory role on p53 a protein important for tumor suppression. Moreover in fibrosis altered HIPK1 activity impacts the TGF-β pathway by interacting with Smad proteins which promotes fibrogenesis. Understanding these connections could facilitate targeting HIPK1 in therapeutic strategies for these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed : 24559171).
See full target information HIPK1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 43:494-500 PubMed37147750

2023

Electroacupuncture alleviates water avoidance stress-induced irritable bowel syndrome in mice by improving intestinal barrier functions and suppressing the expression of inflammatory cytokines.

Applications

Unspecified application

Species

Unspecified reactive species

Sun Mengzhu,Zhang Yujie,Song Yafang,Guo Jing,Wang Yuhang,Xin Chen,G U Dongmei,Sun Jianhua,Pei Lixia
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com