Rabbit Polyclonal H2A acetyl K5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human H2AC4 acetyl K5 conjugated to Ovalbumin.
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Publications
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- Epigenetics & chromatin 9:442016An H4K16 histone acetyltransferase mediates decondensation of the X chromosome in males.
- eLife 5:2016Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.
- Nature medicine 21:1154-622015Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSang-Won Min et. al.PubMed 26390242
- Molecular cell 59:502-112015An Interactive Database for the Assessment of Histone Antibody Specificity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesScott B Rothbart et. al.PubMed 26212453
- Cell cycle (Georgetown, Tex.) 12:2033-412013Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRuozhen Hu et. al.PubMed 23777805
- Cell 148:335-482012Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDominic Schmidt et. al.PubMed 22244452
- PloS one 3:e36502008Analysis of Myc-induced histone modifications on target chromatin.Applications:ChIPReactive species:Unspecified reactive speciesFrancesca Martinato et. al.PubMed 18985155
- Nature 452:492-62008SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
- FEBS letters 581:5275-812007Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation.Applications:WBReactive species:MouseSandra N Garcia,Bhakti M Kirtane,Andrej J Podlutsky,Olivia M Pereira-Smith,Kaoru TominagaPubMed 17961556
- Molecular biology of the cell 18:1098-1062006Np95 is implicated in pericentromeric heterochromatin replication and in major satellite silencing.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRoberto Papait,Christian Pistore,Diego Negri,Daniela Pecoraro,Lisa Cantarini,Ian Marc BonapacePubMed 17182844
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.02% Sodium azide
- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human H2AC4 acetyl K5 conjugated to Ovalbumin. The exact immunogen used to generate this antibody is proprietary information. Database link P04908
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 | Notes - |
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Target data
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Alternative names
H2AFM, HIST1H2AB, H2AC8, H2AFA, HIST1H2AE, H2AC4, Histone H2A type 1-B/E, Histone H2A.2, Histone H2A/a, Histone H2A/m, H2AK5ac
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Rabbit Polyclonal H2A acetyl K5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human H2AC4 acetyl K5 conjugated to Ovalbumin.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.02% Sodium azide
- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human H2AC4 acetyl K5 conjugated to Ovalbumin. The exact immunogen used to generate this antibody is proprietary information. Database link P04908
- Purity
Whole antiserum
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Full details and terms and conditions can be found here:
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Histone H2A (acetyl K5) antibody (ab1764)
IHC image of ab1764 staining Histone H2A (acetyl K5) in human colon formalin fixed paraffin embedded tissue sections, performed on a Leica Bond. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab1764, 1/1000 dilution, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. No primary antibody was used in the negative control (shown on the inset).
For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
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