AB18975

Anti-Histone H2A antibody

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(7 Publications)

Rabbit Polyclonal H2A antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human H2AC4 aa 1-50.

View Alternative Names

H2AFM, HIST1H2AB, H2AC8, H2AFA, HIST1H2AE, H2AC4, Histone H2A type 1-B/E, Histone H2A.2, Histone H2A/a, Histone H2A/m

1 Images

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Western blot - Anti-Histone H2A antibody (AB18975)

All lanes:

Western blot - Anti-Histone H2A antibody (ab18975) at 1 µg/mL

All lanes:

HeLa cell lysate

Predicted band size: 14 kDa

Observed band size: ~14 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human H2AC4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P04908

Specificity

ab18975 does not cross-react with other histones.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 3621 Histone H2A Antibody.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.03% Proclin 300 Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, 0.015% EDTA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

See full target information H2AC4

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

BMC biology 22:188 PubMed39218869

2024

Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1.

Applications

Unspecified application

Species

Unspecified reactive species

Khalid Ouararhni,Flore Mietton,Jamal S M Sabir,Abdulkhaleg Ibrahim,Annie Molla,Raed S Albheyri,Ali T Zari,Ahmed Bahieldin,Hervé Menoni,Christian Bronner,Stefan Dimitrov,Ali Hamiche

Cells 11: PubMed35741067

2022

CFTR Rescue by Lumacaftor (VX-809) Induces an Extensive Reorganization of Mitochondria in the Cystic Fibrosis Bronchial Epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Clarissa Braccia,Josie A Christopher,Oliver M Crook,Lisa M Breckels,Rayner M L Queiroz,Nara Liessi,Valeria Tomati,Valeria Capurro,Tiziano Bandiera,Simona Baldassari,Nicoletta Pedemonte,Kathryn S Lilley,Andrea Armirotti

STAR protocols 1:100178 PubMed33377072

2020

Protocol for Establishing Mouse Embryonic Stem Cells to Study Histone Inheritance Pattern at Single-Cell Resolution.

Applications

Unspecified application

Species

Unspecified reactive species

Binbin Ma,Tung-Jui Trieu,Shukry J Habib,Xin Chen

Aging 12:17099-17113 PubMed32915773

2020

Sirt6 is required for spermatogenesis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Huafang Wei,Muhammad Babar Khawar,Wenhao Tang,Lina Wang,Liying Wang,Chao Liu,Hui Jiang,Wei Li

Cell reports 32:108003 PubMed32783931

2020

Differential Histone Distribution Patterns in Induced Asymmetrically Dividing Mouse Embryonic Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Binbin Ma,Tung-Jui Trieu,Ji Cheng,Shuang Zhou,Qingsong Tang,Jing Xie,Ji-Long Liu,Keji Zhao,Shukry J Habib,Xin Chen

Nature communications 5:5323 PubMed25406515

2014

Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit.

Applications

Unspecified application

Species

Unspecified reactive species

Pavan Kumar Puvvula,Rohini Devi Desetty,Pascal Pineau,Agnés Marchio,Anne Moon,Anne Dejean,Oliver Bischof

Epigenetics & chromatin 6:7 PubMed23570311

2013

Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development.

Applications

Species

Unspecified reactive species

Kelly M Bush,Benjamin Tk Yuen,Bonnie L Barrilleaux,John W Riggs,Henriette O'Geen,Rebecca F Cotterman,Paul S Knoepfler

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Histone H2A antibody

Western blot - Anti-Histone H2A antibody (AB18975)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (7)

Product promise